Stent for increasing blood flow to ischemic tissues and a method of using the same

Patent 6660034 Issued on December 9, 2003. Estimated Expiration Date:

April 30, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Directional drug delivery stent and method of use
Patent #: 6071305
Issued on: 06/06/2000
Inventor: Brown, et al.

Implantable system with drug-eluting cells for on-demand local drug delivery
Patent #: 6206914
Issued on: 03/27/2001
Inventor: Soykan, et al.

Coated implantable medical device
Patent #: 6299604
Issued on: 10/09/2001
Inventor: Ragheb, et al.

Method for treating diseased or damaged organs
Patent #: 6334872
Issued on: 01/01/2002
Inventor: Termin, et al.

Stent with smooth ends
Patent #: 6379379
Issued on: 04/30/2002
Inventor: Wang

Stent with collagen
Patent #: 6391052
Issued on: 05/21/2002
Inventor: Buirge, et al.

Prosthesis with biodegradable surface coating and method for making same
Patent #: 6395023
Issued on: 05/28/2002
Inventor: Summers

Prosthetic vascular graft Patent #: 6436135
Issued on: 08/20/2002
Inventor: Goldfarb

Inventors

Application

No. 09/846498 filed on 04/30/2001

US Classes:

623/1.42Drug delivery

Examiners

Primary: McDermott, Corrine
Assistant: Stewart, Alvin

Attorney, Agent or Firm

Squire, Sanders & Dempsey, L.L.P.

International Classes

A61L 31/14 (20060101)
A61L 31/16 (20060101)
A61F 2/06 (20060101)
A61F 2/00 (20060101)

Abstract

An implantable stent for a vessel includes a tubular body having an inner and outer surface. The inner and outer surfaces are coated with therapeutic substances. The therapeutic substance of the inner surface, such as an angiogenic substance, can be released downstream in the lumen. The therapeutic substance of the outer surface can be applied to the inner surface of the vessel.

Other References

Heeschen et al., Nicotine Stimulates Tumor Angiogenesis, Abstract, American College of Cardiology 50th Annual Scientific Session, Stanford, California, Mar. 18, 2001
Penta et al., Del1 Induces Integrin Signaling and Angiogenesis by Ligation of ଱V댣, J. Biolog. Chem. 274(16):11101-11109 (Apr. 16, 1999)
I. Buschmann, et al., "Arteriogenesis Versus Angiogenesis: Two Mechanisms of Vessel Growth," News Physiol. Sci., vol. 14, pp. 121-125 (Jun. 1999)
A. Helisch, et al., "Angiogenesis and arteriogenesis--not yet for prescription," Z Kardiol, 89, pp. 239-244 (2000)
W.D. Ito, et al., "Monocyte Chemotactic Protein-1 Increases Collateral and Peripheral Conductance After Femoral Artery Occlusion," Circulation Research, vol. 80, No. 6, pp. 829-837 (Jun. 1997)
N. Kipshidze, et al., "Therapeutic Angiogenesis for Critical Limb Ischemia to Limit or Avoid Amputation," The Journal of Invasive Cardiology, vol. 11, No. 1, pp. 25-28 (Jan. 1999)
B.D. Klugherz, et al., "Gene delivery from a DNA controlled-release stent in porcine coronary arteries," Nature Biotechnology, vol. 18, pp. 1181-1184 (Nov. 2000)
J. Li, et al., "PR39, a peptide regulator of angiogenesis," Nature Medicine, vol. 6, No. 1, pp. 49-55 (Jan. 2000)
M. Simons, et al., "Clinical Trials in Coronary Angiogenesis: Issues, Problems, Consensus. An Expert Panel Summary," Circulation, pp. 1-14, (Sep. 2000)
W. Zheng, et al., "Mechanisms of coronary angiogenesis in response to stretch: role of VEGF and TGF-beta," AJP--Heart and Circulatory Physiology, vol. 280, Issue 2, H909-H917, (Feb. 2001)