Photocleavable and acid cleavable linkers for combinatorial chemistry
Patent 6642417 Issued on November 4, 2003. Estimated Expiration Date: 
January 22, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 22, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPhotolabile compounds and methods for their use Photocleavable and acid cleavable linkers for combinatorial chemistry Patent #: 6310244 InventorsAssigneeApplicationNo. 09/766987 filed on 01/22/2001US Classes:564/155, Benzene ring containing204/157.81, Nitrogen product produced564/166, Nitro in substituent Q564/169Carbonyl in substituent QExaminersPrimary: Baker, Maurie GarciaAttorney, Agent or FirmInternational ClassesC07C 235/00 (20060101)C07C 235/06 (20060101) C07B 61/00 (20060101) C08F 8/30 (20060101) C08F 8/28 (20060101) C08F 8/00 (20060101) C07C 205/44 (20060101) C07C 205/37 (20060101) C07C 205/00 (20060101) C07C 59/00 (20060101) C07C 59/74 (20060101) AbstractA substrate for solid phase synthesis comprising a solid phase-linker combination of the formula I is disclosed. Also disclosed are processes for preparing the substrate and chemical intermediates useful therein. Among the novel intermediates are compounds of the formula II wherein R1 is --NO2 or --CHO; R2 is --OCH3, --CHO or --H; R3 is chosen from the group consisting of hydroxyl, the residue of a solid support having a plurality of amino groups, and the residue of an ester, and n=1 or 3-12. ##STR1##A substrate of solid phase synthesis of the formula III is also disclosed. ##STR2##Other References
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