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Methods of using pomegranate extracts for causing regression in lesions due to arteriosclerosis in humans

Patent 6641850 Issued on November 4, 2003. Estimated Expiration Date: Icon_subject November 19, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Application

No. 09/998883 filed on 11/19/2001

US Classes:

424/769, Containing or obtained from a tree having matured height of at least two meters424/776, Containing or obtained from a seed or nut424/777, Containing or obtained from a fruit (aka fructus), including berry514/824ARTERIOSCLEROSIS

Examiners

Primary: Tate, Christopher R.

Attorney, Agent or Firm

International Class

A23L 1/30 (20060101)

Abstract

Methods of using pomegranate extracts of the present invention for treating patients with atherosclerosis, or increased intima-media thickness of an artery, are provided. The methods comprise the step of administering to the patient a composition comprising a therapeutically effective amount of an extract from pomegranate. The methods of the present invention may also be used to decrease the incidence of stroke or heart attack in a patient.

Other References

  • International Product Alert bulletin. Dec. 15, 1997. Rubyan Persia Pomegranate Concentrate Extract. PROMT Database. Full text abstract, 1 p.
  • Glozman et al. Khim.-Farm. Zh. 1989. Vol. 23, No. 9, pp. 111-1115--see full English translation (10 pp.).
  • Kathy K. Griendling, Ph.D. et al.; Oxidate Stress and Cardiovascular Disease; 1997 American Heart Association, Inc.; pp. 3264-3265
  • Judith A. Berliner, Ph.D. et al.; Atherosclerosis: Basic Mechanisms; Circulation 91 (9): 2488; pp. 1-26
  • Aldons J. Lusis; Atherosclerosis; Insight Review Articles; pp. 233-241
  • Michael Aviram; Review of Human Studies on Oxidative Damage and Antioxidant Protection Related to Cardiovascular Diseases; 2000 OPA; pp. 85-97
  • Bianca Fuhrman et al.; Flavonoids Protect LDL from Oxidation and Attenuate Atherosclerosis; 2001 Lippincott Williams & Wilkins; pp. 41-48
  • L. Iuliano, MD et al.; Radiolabeled Native Low-Density Lipoprotein Injected Into Patients With Carotid Stenosis Accumulates in Macrophages of Atherosclerotic Plaque Effect of Vitamin E Supplementation; Circulation Mar. 21, 2000, American Heart Association; pp. 1249-1254
  • Michael Aviram et al.; Paraoxonase Inhibits High-density Lipoprotein Oxidation and Preserves its Functions; The American Society for Clinical Investigation, Inc. Vol. 101, No. 8, Apr. 1998, pp. 1581-1590
  • Mohamad Navab et al.; The Yin and Yang of Oxidation in the Development of the Fatty Streak; 1996 American Heart Association; 16:831-842; pp. 1-24
  • Michael Aviram et al.; Human Serum Paraxonoases (PON1) Q and R Selectively Decrease Lipid Peroxides in Human Coronary and Carotid Atherosclerotic Lesions PON1 Esterase and Peroxidase-Like Activities; 2000 American Heart Associations, Inc.; pp. 2510-2517
  • Michael I. Mackness et al.; Protection of Low-density Lipoprotein Against Oxidative Modification by High-density Lipoprotein Associated Paraoxonase; Atherosclerosis 104 (1993) pp. 129-135
  • Patricia Langley; Why a Pomegranate?; BMJ Volum 321; Nov. 4, 2000; pp. 1153-1154
  • Maria I. Gil et al.; Antioxidant Activity of Pomegranate Juice and Its Relationship with Phenolic Composition and Processing; J. Agric. Food Chem. 2000, 48, pp. 4581-4589
  • Michael Aviram et al.; Pomegranate Juice Consumption Reduces Oxidative Stress, Atherogenic Modifications to LDL, and Platelet Aggregation: Studies in Humans and in Atherosclerotic Apolipoprotein E-deficient Mice; The American Journal of Clinical Nutrition; May 2000 Vol. 71 No. 5; pp. 1062-1076
  • Michael Aviram; Plasma Lipoprotein Separation by Discontinuous Density Gradient Ultracentrifugation in Hyperlipoproteinemic Patients; Biochemical Medicine, Vol. 30, No. 1, Aug. 1983; pp. 111-118
  • Oliver H. Lowry et al.; Protein Measurement With the Folin Phenol Reagent; Department of Pharmacology, Washington University School of Medicine; May 28, 1951; pp. 265-275
  • John A. Buege et al.; Microsomal Lipid Peroxidation; Microsomal Electron Transport and Cyt. P-450; pp. 302-310
  • H. Esterbauer et al., Continuous Monitoring of In Vitro Oxidation of Human Low Density Lipoprotein; Free Rad. Res. Comms. Vol. 6, No. 1, pp. 67-76
  • M. El-Saadani et al.; A spectrophotometric Assay For Lipid Peroxides in Serum Lipoproteins Using a Commercially Available Reagent; Journal of Lipid Research, Vol. 30, 1989; pp. 627-630
  • John C. Khoo et al.; Enhanced Macrophage Uptake of Low Density Lipoprotein After Self-Aggregation; Jul./Aug. 1988; Arteriosclerosis 8:348-358
  • Chris H.A. van de Lest et al.; A Spectrophotometric Method for the Determination of Heparan Sulfate; Biochimica et Biophysicia Acta 1201 (1994) pp. 305-311
  • Gerd Assmann; Quantification of High-Density-Lipoprotein Cholesterol by Precipitation with Phosphotungstic Acid/MgCl2 ; Clin. Chem. 29/12, pp. 2026-2030 (1983)
  • Barry J. Kitchen et al., Effects of Lipid Removal on the Molecular Size and Kinetic Properties of Bovine Plasma Arylesterase; Biochem. J. (1973) 135, pp. 93-99
  • G. Geroulakos et al.; Arterial Wall Changes in Type 2 Diabetic Subjects; pp. 692-695
  • Martin G. Veller et al.; Measurement of the Ultrasonic Intima-Media Complex Thickness in Normal Subjects; Journal of Vascular Surgery, Apr. 1993; pp. 719-725
  • Marielle Kaplan et al.; Pomegranate Juice Supplementation to Atherosclerotic Mice Reduces Macrophage Lipid Peroxidation, Cellular Cholesterol Accumulation and Development of Atherosclerosis; The Journal of Nutrition, Vol. 131, No. 8, Aug. 2001; pp. 2082-2089
  • C. Ben Nasr et al.; Quantitiative Determination of the Polyphenolic Content of Pomegranate Peel; Z. Lebensm Unters Forsch (1996) 203: pp. 374-378
  • T. Mudrikova et al.; Carotid Intima-media Thickness in Relation to Macrovascular Disease in Patients With Type 2 Diabetes Mellitus; National Library of Medicine; Wien Klin Wochenschr Oct. 27, 2000; 112 (20):887-91
  • Toshiyuki Uehara et al.; MR Angiographic Evaluation of Carotid and Intracranial Arteries in Japanese Patients Scheduled for Coronary Artery Bypass Grafting; Cerebrovascular Diseases 2001;11:341-345
  • Eva Lonn MD MSc; Use of Carotid Ultrasound to stratify risk; Can J. Cariol Vol. 17 Suppl. A May 2001; pp. 22A-25A
  • Mehmet S. Ulgen, MD: The Relationship of Coronary Artery Disease and Carotid Doppler Flow Velocity and Resistance Index in Patients with no Significant Carotid Stenosis; Angiology Vol. 52, No. 6, 2001; pp. 433-434
  • John R. Crouse III, MD; Predictive Value of Carotid 2-Dimensional Ultrasound; The American Journal of Cardiology; Vol. 88 (2A) Jul. 19, 2001; pp. 27E-30E
  • D. Ropers et al.; Correlation Between Calcification of the Carotid Arteries Documented by Ultrasound, Coronary Calcifications in Electron-Beam Tomography, and Angiographic Coronary Artery Disease; A Symposium: First International SAI Meeting; p. 85E
  • Nicolas Denarie, MD: Difference in Carotid Artery Wall Structure Between Swedish and French Men at Low and High Coronary Risk; Stroke, Aug. 2001; pp. 1775-1779
  • Tommi Vasankari et al.; Oxidized LDL and Thickness of Carotid Intima-Media are Associated With Coronary Atherosclerosis in Middle-Aged Men: Lower Levels of Oxidized LDL With Statin Therapy; Atherosclerosis 55 (2001); pp. 403-412
  • Olli T. Raitakari et al.; Reduced Myocardial Flow Reserve Relates to Increased Carotid Intima-Media Thickness in Healthy Young Men; Atherosclerosis 156 (2001); pp. 469-475
  • Ward A. Riley, PhD; Reproductivity of Noninvasis Ultrasonic Measurement of Carotid Atherosclerosis The Asymptomatic Carotid Artery Plaque Study; Stroke Vol. 23, No. 8, Aug. 1992; pp. 1062-1068
  • Michiel L. Bots, MD, PhD; Common Carotid Intima-Media Thickness and Risk of Stroke and Myocardial Infarction; Circulation. 1997;96:1432-1437
  • Daniel H. O'Leary, MD: Carotid-Artery Intima and Media Thickness as a Risk Factor For Myocardial Infarction and Stroke in Older Adults; The New England Journal of Medicine; Jan. 7, 1999; pp. 14-22
  • Frank Tietze; Enzymatic Method of Quantitative Determination of Nanogram Amounts of Total and Oxidized Glutathione: Applications to Mammalian Blood and Other Tissues; Analytical Biochemistry 27, 502-522 (1969)
  • Mira Rosenblat et al.; Macrophage Glutathione Content and Glutathione Peroxidase Activity Are Inversely Related to Cell-Mediated Oxidation of LDL: In Vitro and In Vivo Studies; Free Radical Biology & Medicine, Vol. 24, No. 2, pp. 305-317, 1998
  • Cam Patterson et al.; The Oxidation Paradox Another Piece in the Puzzle; Circ. Res. 2000; 87:1074-1076
  • Tiina Rissanen et al.; Low Plasma Lycopene Concentration is Associated With Increased Intima-Media Thickness of the Caroltid Artery Wall; Arterioscler Thromb Vasc Biol. Dec. 2000; pp. 2677-2681
  • Johannes Hulthe et al.; Antibodies to Oxidized LDL In Relation to Intima-Media Thickness in Carotid and Femoral Arteries in 58-Year-Old Subjectively Clinically Healthy Men; Arterioscler Thromb Vasc Biol. pp. 101-107
  • Alexandra Lavy et al.; Enhanced In Vitro Oxidation of Plasma Lipoproteins Derived From Hypercholesterolemic Patients; Metabolism, Vol. 40, No. 8 (Aug.) 1991: pp. 794-799
  • Hermann Esterbauer et al.; Biochemical, Structural, and Functional Properties of Oxidized Low-Density Lipoprotein; Chemical Research in Toxicology, Vol. 3, No. 2, Mar/Apr. 1990 pp. 77-92
  • Michael Aviram et al.; Lesioned Low Density Lipoprotein In A Therosclerotic Apolipoprotein E-Deficient Transgenic Mice And In Humans Is Oxidized And Aggregated; Biochemical and Biophysical Research Communications, Vol. 216, No. 2, 1995, pp. 501-513
  • Jane McElveen et al.; Distribution of Paraoxon Hydrolytic Activity in the Serum of Patients after Myocardial Infarction; Clinical Chemistry, Vol. 32, No. 4, 1986, pp. 671-673
  • Michael I. Mackness et al.; Serum Paraoxonase Activity in Familial Hypercholesterolaemia and Insulin-Dependent Diabetes Mellitus; Atherosclerosis, 86 (1991) pp. 193-199
  • Michael Aviram et al.; Human Paroxonase (PON 1) Is Inactivated By Oxidized Low Density Lipoprotein And Preserved By Antioxidants; Free Radical Biology & Medicine, Vol 26, Nos. 7/8, 1999 pp. 892-904
  • Michael Aviram et al.; Pomegranate Juice Consumption Inhibits Serum Angiotensin Converting Enzyme Activity And Reduces Systolic Blood Pressure; Atherosclerosis 158 (2001) pp. 195-198
  • Kitiyakara et al.; Current Opinion in Nephrology and Hypertension; 1998 Lippincott Williams & Wilkins, Inc., Vol. 7(5) pp. 531-538
  • Eva M. Lonn et al.; Effects of Ramipril and Vitamin E on Atherosclerosis The Study of Evaluate Carotid Ultrasound Changes in Patients Treated With Ramipril and Vitamin E (SECURE); 2001 American Heart Association, Inc. pp. 919-925
  • Ping Sun et al.; Blood Pressure, LDL Cholesterol, and Intima-Media Thickness A Test of the "Response to Injury" Hypothesis of Atherosclerosis; Arterioscler Thromb Vasc. Biol. 2000 American Heart Association, Inc. pp. 2005-2010
  • Caroline A. Abbott et al., Serum Paraoxonase Activity, Concentration, and Phenotype Distribution in Diabetes Mellitus and Its Relationship to Serum Lipids and Lipoproteins; Arteriosclerosis, Thrombosis, and Vascular Biology, 1995;15:1812-1818; 1995 American Heart Association, Inc
  • Michael G L Hertog et al.; Dietary Antioxidant Flavonoids and Risk of Coronary Heart Disease: the Zutphen Elderly Study; The Lancet, Vol. 342, Oct. 23, 1993, pp. 1007-1011
  • Irit Maor et al.; Plasma LDL Oxidation Leads to Its Aggregation in the Atherosclerotic Apolipoprotein E-Deficient Mice; Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17:2995-3005, 1997 American Heart Association, Inc
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