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Platform for the differentiation of cells

Patent 6638765 Issued on October 28, 2003. Estimated Expiration Date: Icon_subject August 3, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Growth of adult pancreatic islet cells Patent #: 5681587
Issued on: 10/28/1997
Inventor: Halberstadt, et al.

Inventor

Assignee

Application

No. 09/890717 filed on 08/03/2001

US Classes:

435/377, Method of altering the differentiation state of the cell424/562, Endocrine system, other than the thymus gland (e.g., parathyroid gland, etc.)424/93.7, Animal or plant cell435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE435/366, Human435/375, Method of regulating cell metabolism or physiology435/395Solid support and method of culturing cells on said solid support

Examiners

Primary: Fredman, Jeffrey
Assistant: Angell, Jon Eric

Attorney, Agent or Firm

International Classes

C12N 5/06 (20060101)
A61K 35/12 (20060101)

Abstract

The present invention relates to an in vitro method for islet cell expansion, which comprises the steps of: a) preparing dedifferentiated cells derived from cells in or associated with post-natal islets of Langerhans; b) expanding the dedifferentiated cells; and c) inducing islet cell differentiation the expanded cells of step b) to become insulin-producing cells.

Other References

  • L Rosenberg, Cell Transplantation, "In Vivo Cell Transformation:Neogenesis of Beta Cells from Pancreatic Ductal Cells," 1995, vol. 4, No. 4, pp. 371-383.
  • Yuan, Songyang et al., "Transdifferentiation of human islets . . . ", Differentiation, (1996) 61, pp. 67-75
  • Hulinsky, Ilja et al., "Insulin secretion and DNA synthesis . . . ", Pancreas, (1995) vol. 11, No. 3, pp. 309-314
  • Kerr-Conte, Julie et al., "Ductal cyst formation . . . ", Diabetes, vol. 45, Aug. 1996, pp. 1108-1114
  • Paraskevas, S. et al., "Apoptosis occurs in freshly . . . ", Transplantation Proceedings, (1997) 29, pp. 750-752
  • Rosenburg, Lawrence, "In vivo cell transformation . . . ", Cell Transplantation, (1995) vol. 4, No. 4, pp. 371-383
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