Patent ReferencesControlled release suppositories Controlled release article with pulsatile release Sustained release suppositories and a process for preparation Patent #: 5436009 InventorsAssigneeApplicationNo. 09/331163 filed on 08/24/1999US Classes:514/653, Hydroxy, bonded directly to carbon, attached directly or indirectly to the acyclic carbon or chain by acyclic nonionic bonding (e.g., beta hydroxy phenethylamines, etc.)514/576Benzene ring containingExaminersPrimary: Criares, Theodore J.Assistant: Kim, Jennifer Attorney, Agent or FirmInternational ClassesA61K 31/137 (20060101)A61K 31/223 (20060101) A61K 31/198 (20060101) A61K 31/185 (20060101) A61K 31/21 (20060101) A61K 31/5575 (20060101) A61K 31/00 (20060101) A61K 31/403 (20060101) A61K 31/4045 (20060101) A61K 31/557 (20060101) A61K 31/485 (20060101) Foreign Application Priority Data1996-12-23 GBAbstractFecal incontinence and anal itch can be treated by administration, more particularly by local application to the anus, of an a adrenergic blocker, nitric oxide synthase inhibitor, prostaglandin F2, dopamine, morphine, ଲ-blockers, and 5-Hydroxytryptamine. The patients who benefit most from the invention are those who have a normal or low maximum anal resting pressure and a structurally intact internal anal sphincter muscle, and patients who have had major bowel resection and reanastomisis.Other References
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