Abstract

A method for diagnosis of a mood disorder or predisposition therefor in a test subject is disclosed. The method includes the steps of determining an interhemispheric switch rate of the test subject, and comparing the switch rate with a corresponding reference switch rate to diagnose presence or absence of the mood disorder or predisposition therefor. In a preferred embodiment, the interhemispheric switch rate is determined by measuring the rate of binocular rivalry in the test subject. Also disclosed is an apparatus for diagnosis of a mood disorder or predisposition therefor, use of the diagnostic method in genetic linkage studies for the identification of the molecular defect(s) underlying these disorders, and for the identification of compounds which may alleviate such disorders.

Other References

• A Hemispheric Basis for the Alternations of Binocular Rivalry? by S. Miller, et al., published in Proceedings in the Australian Physiological and Pharmacological Society (1997)
• A Hemishheric Switch in Binocular Rivalty? by J.D. Pettigrew, et al., published in Proc. Aust. Neuroscience Soc. 1998
• Fluctuation of an Ambiguous Figure in Dementia Praecox and in Manic Depressive Patients by J. McV. Hunt, et al. published in Journal of Abnormal and Social Psychology (1993)
• A Neural Theory of Binocular Rivarly by Randolph Blake, published in Psychological Review 1989
• Interhemispheric Transfer in the Split Brain: Long-term Status Following Complete Cerebral Commissurotomy by Eran Zaidel published 1995
• What is Rivalling During Binocular Rivalry by N.K. Logothetis, et al., published 1996
• The Ultradian Rhythm of Alternating Cerebral Hemispheric Activity by D. Shannahoff-Khalsa published 1993
• A "Sticky" Interhemispheric Switch in Bipolar Disorder? by J.D. Pettigrew, et al. published 1998
• Independent Hemispheric Attentional Systems Mediate Visual Search in Split-Brain Patients by S.J. Luck, et al. published 1989