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Treatments for restless legs syndrome

Patent 6602868 Issued on August 5, 2003. Estimated Expiration Date: Icon_subject October 29, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Heterocyclic amines having central nervous system activity
Patent #: 5273975
Issued on: 12/28/1993
Inventor: Moon, et al.

Heterocyclic amines having central nervous system activity
Patent #: 5436240
Issued on: 07/25/1995
Inventor: Moon, et al.

Centrally acting substituted phenylazacycloalkanes
Patent #: 5462947
Issued on: 10/31/1995
Inventor: Svensson, et al.

Centrally actig substituted phenylazacycloalkanes
Patent #: 5594024
Issued on: 01/14/1997
Inventor: Svensson, et al.

Use of pramipexole in the treatment of restless legs syndrome
Patent #: 6001861
Issued on: 12/14/1999
Inventor: Oertel, et al.

Use of cabergoline in the treatment of restless legs syndrome Patent #: 6114326
Issued on: 09/05/2000
Inventor: Schueler

Inventors

Assignee

Application

No. 039446 filed on 10/29/2001

US Classes:

514/224.2, Polycyclo ring system having the six-membered hetero ring as one of the cyclos (e.g., 1,3- and 1,4- benzothiazines, etc.)514/228.2, Polycyclo ring system having the additional hetero ring as one of the cyclos514/230.2, Ring nitrogen shared by two of the cyclos514/233.2, Ring nitrogen shared by two of the cyclos514/250, At least three rings in the polycyclo ring system514/291, Plural hetero atoms in the tricyclo ring system514/292, Plural ring nitrogens in the tricyclo ring system514/293, Three or more hetero atoms in the tricyclo ring system514/294Ring nitrogen is shared by two of the cyclos

Examiners

Primary: Reamer, James H.

Attorney, Agent or Firm

Foreign Patent References

  • 2002/0068692 Willis 06/13/2012
  • WO 92 18475 WO. 10/13/1992
  • WO 99 16442 WO 04/13/1999
  • WO 00 03714 WO. 01/13/2012
  • WO 00 40226 WO 07/13/2012
  • WO 01/13903 2 WO 03/13/2012
  • WO 01/81343 WO 11/13/2012
  • WO 01 83483 WO 11/13/2012

International Class

A61K 031/50

Abstract

The invention provides methods and use of heterocyclic amines, and phenylazacycloalkane compounds, and their pharmacologically acceptable salts for the treatment of Restless Legs Syndrome (RLS).

Other References

  • Collado-Seidel V et al: "Aetiology and Treatment of Restless Legs Syndrome" CNS Drugs, ADIS International, Auckland, NZ, vol. 12, No. 1, 1999, pp. 9-20, XP0000989833
  • Ekesbo, Anna et al: "Effects of the substituted (S)-3-Phenylpiperidine(-)-OSU6162 on PET measurements of [11C]SCH23390 and [11C] raclopride binding in primate brains" Neuropharmacology (1999), 38 (3) , 331-338, XP002200122
  • Sethy, Vimala H. et al: "U-95666E: a potential anti-parkinsonian drug with anxiolytic activity" Prog. Neuro-Psychopharmacol. Biol. Psychiatry (1997), 21(5), 873-883, XP002192219, p. 874, paragraph 2, p. 878, paragraph 2
  • Walters A S et al: "A Double-Blind Randomized Crossover Trial of Bromocriptine and Placebo in Restless Legs Syndrome" Annals of Naeurology, Boston, US, vol. 24, No. 3, Sep. 1998 (1988-09), pp. 455-458, XP002117258
  • SAkipinar, Restless Legs Syndrome Treatment with Dopaminergic Drugs, Clinical Neuropharmacology, vol. 10, pp. 69-79
  • CBrodeur, et al., "Treatment of RLS and PMS with L-dopa: A Double Blinded Control Study", Neurology, 1988, vol. 35, pp. 1845-1848
  • KAEkbom, "Restless Legs Syndrome", Neurology, 1960, vol. 10, pp. 868-873
  • WAHening, et al, Dykinesias While Awake and Periodic Movements in Sleep in Restless Legs Syndrome: Treatment with Opioids, Neurology, 1986, vol. 36, pp1363-1366
  • JMontplaisir, et. al., "Restless Legs Syndrome and Periodic Movements in Sleep: Physiopathology and Treatment with L-dopa", Clinical Neuropharmacology, 1986, vol. 9, pp. 456-463
  • Trzepacz, PT, Violette EJ, Sateia MJ and Hening WA, "Response to Opioids in Three Patients with Restless Legs Syndrome", Am. J. Psychiatry, 1984, vol. 141, pp993-999
  • CvonScheele, Levodopa in Restless Legs, The Lancet, Aug. 23, 1986, pp. 426-427
  • ASWalters, et.al., "A Double Blinded Randomized CrossoverTrial of Bromocriptine and Placebo in Restless Leg Syndrome", Ann Neurol, 1988, vol. 24, pp. 455-45
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