Osmotic device containing alprazolam and an antipsychotic agent
Patent 6599532 Issued on July 29, 2003. Estimated Expiration Date: 
January 8, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 8, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesTransdermal administration of short or intermediate half-life benzodiazepines Delivery device having encapsulated excipients Sustained release microsphere preparation containing antipsychotic drug Multi-layered osmotic device Patent #: 6004582 InventorsAssigneeApplicationNo. 756497 filed on 01/08/2001US Classes:424/472, Layered unitary dosage forms424/468, Sustained or differential release type424/474, Coated pills or tablets424/475, Organic coatings424/479, Containing polysaccharide (e.g., sugar, etc.)424/480, Cellulose or derivative424/482, Containing solid synthetic polymers424/722, Alkali metal or alkaline earth containing514/220, Tricyclo ring system having the seven-membered hetero ring as one of the cyclos514/226.2, Chalcogen or nitrogen attached indirectly to the phenothiazine ring nitrogen by acyclic nonionic bonding514/259.41, Additional hetero ring is attached directly or indirectly to the bicyclo ring system by nonionic bonding514/317Additional ring containingExaminersPrimary: Hartley, Michael G.Assistant: Gollamudi, Sharmila S Attorney, Agent or FirmInternational ClassesA61K 009/24A61K 009/22 A61K 009/28 A61K 009/36 A61K 009/32 AbstractThe present invention provides an osmotic device containing controlled release alprazolam in the core optionally in combination with an anti-psychotic agent, in a rapid release external coat. A wide range of anti-psychotic agents can be used in this device. Particular embodiments of the invention provide osmotic devices having predetermined release profiles. One preferred embodiment of the osmotic device includes an external coat that has been spray coated rather compression coated onto the device. The device with spray coated external core is smaller and easier to swallow than the similar device having a compression coated external coat. The device is useful for the treatment of depression, anxiety or psychosis related disorders.Other References
Field of SearchContaining polysaccharide (e.g., sugar, etc.)PREPARATIONS CHARACTERIZED BY SPECIAL PHYSICAL FORM Tablets, lozenges, or pills Sustained or differential release type Layered unitary dosage forms With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.) Coated pills or tablets Organic coatings Containing waxes, higher fatty acids, higher fatty alcohols, or derivatives thereof (e.g., chocolate) SUSTAINED OR DIFFERENTIAL RELEASE TYPE | |
