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US Patent 6579854 - Diagnosis and management of infection caused by chlamydia

US Patent Issued on June 17, 2003
Estimated Patent Expiration Date: Icon_subject May 6, 2018Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The present invention provides a unique approach for the diagnosis and management of infections by Chlamydia species, particularly C. pneumoniae. The invention is based, in part, upon the discovery that a combination of agents directed toward the various stages of the chlamydial life cycle is effective in substantially reducing infection. Products comprising combination of antichlamydial agents, novel compositions and pharmaceutical packs are also described.

Other References

  • Windholz et al., The Merck Index, Tenth Edition (1983), pp. 531, 532, 1017 and 1187.
  • Budavari et al., the Merck Index, Twelfth Edition (1996), pp 157.
  • Wang et al., Effects of Ascorbic Acid on Chlamydia Trachomatis Infection and on Erythromycin Treatment in Primary Cultures of Human Amniotic Cells. J.Clin.Microbiol, 30. 2551-2554, 1992.
  • Bertrand et al., "L'Ofloxacine (RU 43280) Etude Clinique," Path. Biol., 35: 629-633, 1987
  • Drancourt et al., "Oral Rifampin plus Ofloxacin for Treatment of Staphylococcus -Infected Orthopedic Implants," Antimicrobial Agents and Chemotherapy, 37: 1214-1218, 1993
  • Freidank et al., "In Vitro Susceptibilities of Chlamydia pneumoniae Isolates from German Patients and Synergistic Activity of Antibiotic Combinations," Antimicrobial Agents and Chemotheraphy, 43: 1808-1810, 1999
  • Jones et al., "In Vitro Activity of Rifamycins Alone and in Combination with Other Antibiotics Against Chlamydia trachomatis," Reviews of the Infectious Diseases, 5: S556-S564, 1983
  • Miettinen, A., et al., "The Effect of Ciprofloxacin and Doxycycline Plus Metronidazole on Lower Genital Tract Flora in Patients with Proven Pelvic Inflammatory Disease", Arch. Gynecol. Obstet., 249: 95-101 (1991)
  • Judlin, P., et al., "Etude Comparative Des Associations Ofloxacine + Amoxicilline-Acide Clavulanique Versus Doxycycline + Amoxicilline-Acid Clavulanique Dans Le Traitement Des Infections Genitales Hautes A Chlamydia trachomatis", J. Gynecol. Obstet. Biol. Reprod., 24: 253-259 (1995)
  • Henry-Suchet, J., "Traitement Des Infections Utero-Annexielles Sexuellement Transmises (IUAST) Sauf Syphilis Et Herpes", Med. Mal. Infect., 24: 379-387 (1994)
  • Joly-Guillou, M.L., et al., "Bacteries Isolees En 1994-1995 Au Cours Des Infections Gynecologiques Hautes Et Des Urethrites Masculines", La Presse Medicale 2-9 Mars. 25, (8): 342-348
  • Orfila, J. and Haider, F., "Comparative Study Of The In Vitro Activity Of Lomefloxacin Versus Lomefloxacin Combined With Metronidazole Versus Lomefloxacin In Combination With Amoxicilli/Clavulanic Acid Against Chlamydia trachomatis", Intern. J. Antimicro. Agents, 2: 11-14 (1992)
  • Witte, E.H., et al., "A Comparison Of Pefloxacin/Metronidazole And Doxycycline/Metronidazole in the Treatment of Laparoscopically Confirmed Acute Pelvic Inflammatory Disease", Eur. J. Obstet. Gynec. and Repro. Bio., 50:153-158 (1993)
  • Heinonen, Pentti K., et al., "A Comparison of Ciprofloxacin with Doxycycline plus Metronidazole in the Treatment of Acute Pelvic Inflammatory Disease", Scand. J. Infect. Dis. Suppl., 60: 66-73 (1989)
  • Burchell, H.J., et al., "Efficacy of Different Antibiotics in the Treatment of Pelvic Inflammatory Disease", SAMJ., 72: 248-249 (Aug. 15, 1987)
  • Paavonen, J., et al., "Factors Predicting Abnormal Hysterosal-pingographic Findings in Patients Treated for Acute Pelvic Inflammatory Disease", Int. J. Gynaecol. Obstet., 23: 171-175 (1985)
  • The Merck Manual of Diagnosis and Therapy, 16th Ed., pp. 181-182, 257-258 and 691-694 (1992)
  • Schachter, "Rifampin in Chlamydial Infections,"Reviews of Infectious Diseases, 5;S 562-S564, 198

Inventors

Assignee

Application

No. 073661 filed on 05/06/1998

US Classes:

514/31, The hetero ring has 20 or more ring carbons (e.g., nystatin, etc.)514/152, 3,10-dihydroxy-2-naphthacene carboxamide or derivative (e.g., tetracycline, etc.) DOAI514/192, 1-thia-4-aza-bicyclo (3.2.0) heptane ring containing (including dehydrogenated) (e.g., penicillins, etc.)514/198, Ampicillin per se or salt thereof514/311, Quinolines (including hydrogenated)514/601, Sulfonamides (i.e., Q-(O=)S(=O)-N, wherein Q is a substituent and wherein any substituent attached to the nitrogen will be referred to as E)514/631Amidines (i.e., N=C-N)

Field of Search

424/114, PLURAL FERMENTATES OF DIFFERENT ORIGIN (E.G., MIXTURES OF ANTIBIOTICS, ETC.)424/263.1, Chlamydia (e.g., Chlamydia trachomatis, etc.)436/518, INVOLVING AN INSOLUBLE CARRIER FOR IMMOBILIZING IMMUNOCHEMICALS436/6, Corrosion resistance or power435/7.2, Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate530/389.5, Binds bacterium or similar microorganism or component or product thereof (e.g., Pseudomonas, Chlamydia, Clostridium, bacterium-associated antigen, etc.)530/350, PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES536/16.8, Antibiotics536/23.1, DNA or RNA fragments or modified forms thereof (e.g., genes, etc.)536/24.3, Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA536/24.32, Probes for detection of microbial nucleotide sequences514/31, The hetero ring has 20 or more ring carbons (e.g., nystatin, etc.)514/631, Amidines (i.e., N=C-N)514/152, 3,10-dihydroxy-2-naphthacene carboxamide or derivative (e.g., tetracycline, etc.) DOAI514/192, 1-thia-4-aza-bicyclo (3.2.0) heptane ring containing (including dehydrogenated) (e.g., penicillins, etc.)514/198, Ampicillin per se or salt thereof514/601, Sulfonamides (i.e., Q-(O=)S(=O)-N, wherein Q is a substituent and wherein any substituent attached to the nitrogen will be referred to as E)514/311Quinolines (including hydrogenated)

Examiners

Primary: Weddington, Kevin E.

Attorney, Agent or Firm

US Patent References

4952594, Reagents and method for therapeutic treatment of multiple sclerosis
Issued on: 08/28/1990
Inventor: Mercer
5217493, Antibacterial coated medical implants
Issued on: 06/08/1993
Inventor: Raad, et al.
5424187, Method of screening for arterial chlamydial granuloma
Issued on: 06/13/1995
Inventor: Shor, et al.
5650405, Treatment for toxoplasmosis with a composition comprising a sulfonamide and a spiropiperidyl derivative of rifamycin S.
Issued on: 07/22/1997
Inventor: Remington, et al.
5795563, Identification of an exogenous intra-erythrocytic bacterium in patients having systemic lupus erythematosus, and treatment
Issued on: 08/18/1998
Inventor: Kallick
5880101, Clinical uses of polyene macrolides
Issued on: 03/09/1999
Inventor: Stankov
6258532Methods for in vitro susceptibility testing of chlamydia
Issued on: 07/10/2001
Inventor: Stratton, et al.

Foreign Patent References

  • 0 337 733 EP. 10/09/1989
  • 0 546 761 EP. 06/09/1993
  • 0 699 688 EP. 03/09/1996
  • 0 192 033 EP. 08/09/1996
  • WO 98/06435 WO. 02/09/1998
  • 98/50074 WO. 11/09/1998
  • WO9220352 WO. 11/09/1999

International Classes

A61K 031/70
A61K 031/65
A61K 031/43
A61K 031/47
A61K 031/18

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