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US Patent 6565895 - Bismuth compounds for the treatment and prevention of mucositis

US Patent Issued on May 20, 2003
Estimated Patent Expiration Date: Icon_subject June 8, 2021Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

The invention relates to the unexpected discovery that bismuth-containing compounds are effective in the treatment of oral mucositis in a mammal. Thus, the invention relates, in one aspect to a method of treating oral mucositis comprising administering an effective amount of a pharmaceutically acceptable bismuth-containing compound, such as a bismuth salt or bismuth complex. In a preferred embodiment, the bismuth compound is an organic or inorganic salt such as, bismuth subsalicylate, bismuth subgallate, bismuth aluminate, bismuth citrate, bismuth subcitrate, bismuth carbonate, bismuth subcarbonate, tripotassium dicitrato bismuthate, bismuth nitrate, bismuth subnitrate, bismuth tartrate and mixtures thereof, preferably, bismuth subsalicylate and bismuth subgallate.

Other References

  • Hild, Gunter., "An Article Concerning Rectal Bismuth Therapy in Angina Tonsillaris, Pharyngitis and Inflammation of Mucous Membrane of the Mouth," Medizinische, 40:1879-1886 (1959). English translation of entire article included
  • Sun et al., "Bismuth Antiulcer Complexes," Topics in Biological Inorganic Chemistry, 2:159-185 (1999)
  • Brian et al., "Bismuth Compounds and Preparations with Biological or Medicinal Relevance" Chemical Reviews, 99(9) :2601-2657 (1999)
  • Israel et al., "Topical Dehydroascorbic Acid (DHA) Reduces Moderate to Severe Mucositis in the Hamster Acute Radiation Model," Program/Proceedings of the American Society of Clinical Oncology. Thirty-sixth Annual Meeting, New Orleans, LA, May 20-23, 200

Inventors

Application

No. 877723 filed on 06/08/2001

US Classes:

424/653, Bismuth424/49, DENTIFRICES (INCLUDES MOUTH WASH)424/53, Oxygen or chlorine releasing compound containing514/6, Heavy metal containing (e.g., hemoglobin, etc.)514/184, Heavy metal containing (including salts)514/503, Antimony or bismuth514/557, Carboxylic acid, percarboxylic acid, or salt thereof (e.g., peracetic acid, etc.)514/574, Polycarboxylic acid or salt thereof514/901, Mouthwash514/902, Gingival514/925, ULCER TREATMENT514/928Topical

Field of Search

424/653, Bismuth424/49, DENTIFRICES (INCLUDES MOUTH WASH)424/53, Oxygen or chlorine releasing compound containing514/503, Antimony or bismuth514/901, Mouthwash514/902, Gingival514/925, ULCER TREATMENT514/928, Topical514/184, Heavy metal containing (including salts)514/557, Carboxylic acid, percarboxylic acid, or salt thereof (e.g., peracetic acid, etc.)514/574Polycarboxylic acid or salt thereof

Examiners

Primary: Pak, John

Attorney, Agent or Firm

US Patent References

2259492, 2312195, 2427692, 3651207, 3651208, 4457909, Oral rinse formulation and method of treating mouth and throat irritations therewith
Issued on: 07/03/1984
Inventor: Tames
4801454, Processes for making colored pharmaceutical compositions
Issued on: 01/31/1989
Inventor: Coveney
4940695, Bismuth-containing pharmaceutical compositions
Issued on: 07/10/1990
Inventor: Coveney, et al.
5013560, Microbially-stable bismuth-containing liquid pharmaceutical suspensions
Issued on: 05/07/1991
Inventor: Stentz, et al.
5128334, Analgesic and anti-inflammatory medicine
Issued on: 07/07/1992
Inventor: Nishikawa, et al.
5234908, Method of treating gastrointestinal ulcers with platelet derived growth factor
Issued on: 08/10/1993
Inventor: Szabo, et al.
5281196Skin treatment composition and method of use
Issued on: 01/25/1994
Inventor: Sultenfuss

Foreign Patent References

  • 1734760 SU. 09/09/1989
  • WO 01/12128 WO. 02/09/2010

International Classes

A61K 033/24
A61K 031/28
A61K 033/00
A61K 033/06

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