3M employee and church chorister Art Fry needed something to temporarily mark pages in his hymnal. He was in luck because his colleague, Spencer Silver, accidentally developed a glue that was too weak for other purposes. After initially discouraging consumer response, Post-it Notes became a hit in 1979.
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AbstractThe invention relates to the unexpected discovery that bismuth-containing compounds are effective in the treatment of oral mucositis in a mammal. Thus, the invention relates, in one aspect to a method of treating oral mucositis comprising administering an effective amount of a pharmaceutically acceptable bismuth-containing compound, such as a bismuth salt or bismuth complex. In a preferred embodiment, the bismuth compound is an organic or inorganic salt such as, bismuth subsalicylate, bismuth subgallate, bismuth aluminate, bismuth citrate, bismuth subcitrate, bismuth carbonate, bismuth subcarbonate, tripotassium dicitrato bismuthate, bismuth nitrate, bismuth subnitrate, bismuth tartrate and mixtures thereof, preferably, bismuth subsalicylate and bismuth subgallate.Other References
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ApplicationNo. 877723 filed on 06/08/2001US Classes:424/653, Bismuth424/49, DENTIFRICES (INCLUDES MOUTH WASH)424/53, Oxygen or chlorine releasing compound containing514/6, Heavy metal containing (e.g., hemoglobin, etc.)514/184, Heavy metal containing (including salts)514/503, Antimony or bismuth514/557, Carboxylic acid, percarboxylic acid, or salt thereof (e.g., peracetic acid, etc.)514/574, Polycarboxylic acid or salt thereof514/901, Mouthwash514/902, Gingival514/925, ULCER TREATMENT514/928TopicalField of Search424/653, Bismuth424/49, DENTIFRICES (INCLUDES MOUTH WASH)424/53, Oxygen or chlorine releasing compound containing514/503, Antimony or bismuth514/901, Mouthwash514/902, Gingival514/925, ULCER TREATMENT514/928, Topical514/184, Heavy metal containing (including salts)514/557, Carboxylic acid, percarboxylic acid, or salt thereof (e.g., peracetic acid, etc.)514/574Polycarboxylic acid or salt thereofExaminersPrimary: Pak, JohnAttorney, Agent or FirmUS Patent References2259492, 2312195, 2427692, 3651207, 3651208, 4457909, Oral rinse formulation and method of treating mouth and throat irritations therewithIssued on: 07/03/1984 Inventor: Tames4801454, Processes for making colored pharmaceutical compositions Issued on: 01/31/1989 Inventor: Coveney4940695, Bismuth-containing pharmaceutical compositions Issued on: 07/10/1990 Inventor: Coveney, et al.5013560, Microbially-stable bismuth-containing liquid pharmaceutical suspensions Issued on: 05/07/1991 Inventor: Stentz, et al.5128334, Analgesic and anti-inflammatory medicine Issued on: 07/07/1992 Inventor: Nishikawa, et al.5234908, Method of treating gastrointestinal ulcers with platelet derived growth factor Issued on: 08/10/1993 Inventor: Szabo, et al.5281196Skin treatment composition and method of use Issued on: 01/25/1994 Inventor: Sultenfuss Foreign Patent References
International ClassesA61K 033/24A61K 031/28 A61K 033/00 A61K 033/06 |