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Methods of spray drying pharmaceutical compositions

Patent 6565885 Issued on May 20, 2003. Estimated Expiration Date: Icon_subject December 22, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3014844

Rosmarinic acid-phospholipide-complex
Patent #: 4358442
Issued on: 11/09/1982
Inventor: Wirtz-Peitz ,   et al.

Process for drying and expanding microspheres
Patent #: 4397799
Issued on: 08/09/1983
Inventor: Edgren ,   et al.

Lipid and protein containing material in particulate form and process therefor
Patent #: 4404228
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Composition for curing respiratory diseases
Patent #: 4571334
Issued on: 02/18/1986
Inventor: Yoshida ,   et al.

Inhalation pharmaceuticals
Patent #: 4590206
Issued on: 05/20/1986
Inventor: Forrester ,   et al.

Artificial surfactants, pharmaceutical compositions containing them and use thereof
Patent #: 4765987
Issued on: 08/23/1988
Inventor: Bonte ,   et al.

Porous microspheres for drug delivery and methods for making same
Patent #: 4818542
Issued on: 04/04/1989
Inventor: DeLuca ,   et al.

Drug delivery system
Patent #: 4904479
Issued on: 02/27/1990
Inventor: Illum

Composition and method for administration of pharmaceutically active substances
Patent #: 5011678
Issued on: 04/30/1991
Inventor: Wang, et al.

More ...

Inventors

Application

No. 219736 filed on 12/22/1998

US Classes:

424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/9.52, Stable gas bubbles containing or intentional solubilized gas containing424/43, EFFERVESCENT OR PRESSURIZED FLUID CONTAINING424/45, Organic pressurized fluid424/450, Liposomes424/487, Acrylic acid and derivatives514/3, Insulin or derivative514/4With an additional active ingredient

Examiners

Primary: Dees, Jose G.
Assistant: Haghighatian, M.

Attorney, Agent or Firm

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International Classes

A61K 009/14
A61K 009/12
A61K 009/127
A61K 047/16

Abstract

Spray drying methods for forming powder compositions for pharmaceutical applications are disclosed. According to one aspect of the invention, the spray drying feed stock comprises a bioactive agent, surfactant, and a blowing agent. Another aspect of the invention is directed to spray drying a feed stock comprising a phospholipid and calcium chloride.

Other References

  • Pharmaceutical Res., vol. 16, No. 4, p. 555-61 (1999).
  • Lwandiko E. Masinde, et al. Aerosolized Aqueous Suspensions of Poly(L-lactic Acid) Microspheres. 100 International Journal of Pharmaceutics (1993) 123-131
  • Donna L. French et al., The Influence of Formulation on Emission, Deaggregation and Deposition of Dry Powders for Inhalation, J. Aerosol Sci., vol. 27, No. 5, pp. 769-783 (1996)
  • C. Roth et al., "Production of Hollow Spheres," Pargamon Press, vol. 19 (No. 7), pp. 939-942, 199
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