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US Patent 6565885 - Methods of spray drying pharmaceutical compositions

US Patent Issued on May 20, 2003
Estimated Patent Expiration Date: Icon_subject December 22, 2018Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Spray drying methods for forming powder compositions for pharmaceutical applications are disclosed. According to one aspect of the invention, the spray drying feed stock comprises a bioactive agent, surfactant, and a blowing agent. Another aspect of the invention is directed to spray drying a feed stock comprising a phospholipid and calcium chloride.

Other References

  • Pharmaceutical Res., vol. 16, No. 4, p. 555-61 (1999).
  • Lwandiko E. Masinde, et al. Aerosolized Aqueous Suspensions of Poly(L-lactic Acid) Microspheres. 100 International Journal of Pharmaceutics (1993) 123-131
  • Donna L. French et al., The Influence of Formulation on Emission, Deaggregation and Deposition of Dry Powders for Inhalation, J. Aerosol Sci., vol. 27, No. 5, pp. 769-783 (1996)
  • C. Roth et al., "Production of Hollow Spheres," Pargamon Press, vol. 19 (No. 7), pp. 939-942, 199

Inventors

Application

No. 219736 filed on 12/22/1998

US Classes:

424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/9.52, Stable gas bubbles containing or intentional solubilized gas containing424/43, EFFERVESCENT OR PRESSURIZED FLUID CONTAINING424/45, Organic pressurized fluid424/450, Liposomes424/487, Acrylic acid and derivatives514/3, Insulin or derivative514/4With an additional active ingredient

Field of Search

424/45, Organic pressurized fluid424/46, Powder or dust containing424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/43, EFFERVESCENT OR PRESSURIZED FLUID CONTAINING424/9.52, Stable gas bubbles containing or intentional solubilized gas containing424/487, Acrylic acid and derivatives424/450, Liposomes514/937, DISPERSION OR EMULSION514/3, Insulin or derivative514/4, With an additional active ingredient530/303, Insulin; related peptides530/304, Metal complexes, e.g., Zn-insulin, etc.530/305Isolation or purification

Examiners

Primary: Dees, Jose G.
Assistant: Haghighatian, M.

Attorney, Agent or Firm

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International Classes

A61K 009/14
A61K 009/12
A61K 009/127
A61K 047/16

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