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US Patent 6565832 - Spray composition with reduced dripping
US Patent Issued on May 20, 2003
Estimated Patent Expiration Date:
January 31, 2020Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
January 31, 2020Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.ClaimsWhat is claimed is: 1. A nasal spray composition comprising water, oxymetazoline hydrochloride, about 2.5 to about 3.5 weight percent of a mixture of microcrystalline cellulose and an alkali metal carboxyalkylcellulose, and about 0.5 to about 5 weight percent of polyvinylpyrrolidone, wherein complex viscosity of the composition increases to at least about 10 times a minimum complex viscosity of the composition as measured under high shear conditions, within about 20 seconds after the high shear conditions terminate. 2. The nasal spray composition of claim 1, wherein the alkali metal carboxyalkylcellulose is sodium carboxymethylcellulose. 3. The nasal spray composition of claim 2, wherein microcrystalline cellulose comprises between about 85 and about 95 percent by weight of the mixture with sodium carboxymethylcellulose. 4. A nasal spray composition comprising: water; a nasal decongestant comprising oxymetazoline hydrochloride; about 2.5 to about 3.5 percent by weight of a mixture of microcrystalline cellulose and an alkali metal carboxyalkylcellulose; and about 0.5 to about 5 percent by weight of a rheology-modifying polymer; wherein complex viscosity of the composition increases to at least about 10 times a minimum complex viscosity of the composition as measured under high shear conditions, within about 20 seconds after the high shear conditions terminate. 5. A nasal spray composition comprising: water, a nasal decongestant comprising oxymetazoline hydrochloride; about 2.5 to about 3.5 percent by weight of a mixture of microcrystalline cellulose and an alkali metal carboxyalkylcellulose; and about 0.5 to about 5 percent by weight of a rheology-modifying polymer comprising polyvinylpyrrolidone; wherein complex viscosity of the composition increases to at least about 10 times a minimum complex viscosity of the composition as measured under high shear conditions, within about 20 seconds after the high shear conditions terminate. | InventorsAssigneeApplicationNo. 494574 filed on 01/31/2000US Classes:424/45, Organic pressurized fluid424/78.04, Ophthalmic preparation424/434, Mucosal (e.g., nasal, etc.)514/853DECONGESTANTField of Search424/45, Organic pressurized fluid424/78.04, Ophthalmic preparation424/78.08, SOLID SYNTHETIC ORGANIC POLYMER AS DESIGNATED ORGANIC ACTIVE INGREDIENT (DOAI)424/601, Phosphorus or phosphorus compound424/434, Mucosal (e.g., nasal, etc.)514/912, OPHTHALMIC514/853, DECONGESTANT514/937DISPERSION OR EMULSIONExaminersPrimary: Hartley, Michael G.Assistant: Haghighatian, M. Attorney, Agent or FirmUS Patent References5854269, Nasal spray compositionsIssued on: 12/29/1998 Inventor: Haslwanter, et al.5897858, Nasal spray compositions exhibiting increased retention in the nasal cavity Issued on: 04/27/1999 Inventor: Haslwanter, et al.5976573, Aqueous-based pharmaceutical composition Issued on: 11/02/1999 Inventor: Kim6368616Aqueous suspension for nasal administration of loteprednol Issued on: 04/09/2002 Inventor: Doi International ClassesA61K 009/12A61K 009/08 |
