Spray composition with reduced dripping
Patent 6565832 Issued on May 20, 2003. Estimated Expiration Date: 
January 31, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 31, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesNasal spray compositions Nasal spray compositions exhibiting increased retention in the nasal cavity Aqueous-based pharmaceutical composition Aqueous suspension for nasal administration of loteprednol Patent #: 6368616 InventorsAssigneeApplicationNo. 494574 filed on 01/31/2000US Classes:424/45, Organic pressurized fluid424/78.04, Ophthalmic preparation424/434, Mucosal (e.g., nasal, etc.)514/853DECONGESTANTExaminersPrimary: Hartley, Michael G.Assistant: Haghighatian, M. Attorney, Agent or FirmInternational ClassesA61K 009/12A61K 009/08 ClaimsWhat is claimed is: 1. A nasal spray composition comprising water, oxymetazoline hydrochloride, about 2.5 to about 3.5 weight percent of a mixture of microcrystalline cellulose and an alkali metal carboxyalkylcellulose, and about 0.5 to about 5 weight percent of polyvinylpyrrolidone, wherein complex viscosity of the composition increases to at least about 10 times a minimum complex viscosity of the composition as measured under high shear conditions, within about 20 seconds after the high shear conditions terminate. 2. The nasal spray composition of claim 1, wherein the alkali metal carboxyalkylcellulose is sodium carboxymethylcellulose. 3. The nasal spray composition of claim 2, wherein microcrystalline cellulose comprises between about 85 and about 95 percent by weight of the mixture with sodium carboxymethylcellulose. 4. A nasal spray composition comprising: water; a nasal decongestant comprising oxymetazoline hydrochloride; about 2.5 to about 3.5 percent by weight of a mixture of microcrystalline cellulose and an alkali metal carboxyalkylcellulose; and about 0.5 to about 5 percent by weight of a rheology-modifying polymer; wherein complex viscosity of the composition increases to at least about 10 times a minimum complex viscosity of the composition as measured under high shear conditions, within about 20 seconds after the high shear conditions terminate. 5. A nasal spray composition comprising: water, a nasal decongestant comprising oxymetazoline hydrochloride; about 2.5 to about 3.5 percent by weight of a mixture of microcrystalline cellulose and an alkali metal carboxyalkylcellulose; and about 0.5 to about 5 percent by weight of a rheology-modifying polymer comprising polyvinylpyrrolidone; wherein complex viscosity of the composition increases to at least about 10 times a minimum complex viscosity of the composition as measured under high shear conditions, within about 20 seconds after the high shear conditions terminate. |
