U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Vasodilator cannabinoid analogs

Patent 6563009 Issued on May 13, 2003. Estimated Expiration Date: Icon_subject March 8, 2022. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans
Patent #: 4025516
Issued on: 05/24/1977
Inventor: Razdan ,   et al.

Process for the preparation of (-)-6a,10a-trans-6a,7,8,10a-tetrahydrodibenzo[b,d]-pyrans
Patent #: 4116979
Issued on: 09/26/1978
Inventor: Razdan ,   et al.

Cardiovascular uses of cannabinoid compounds
Patent #: 5939429
Issued on: 08/17/1999
Inventor: Kunos, et al.

Alkylated resorcinol derivatives for the treatment of immune diseases Patent #: 6274635
Issued on: 08/14/2001
Inventor: Travis

Inventors

Assignee

Application

No. 009813 filed on 03/08/2002

US Classes:

568/743The additional ring is six-membered

Examiners

Primary: Shippen, Michael L.

Attorney, Agent or Firm

Foreign Patent References

  • WO 99/53917 WO. 10/13/1999

International Class

C07C 039/17

Abstract

Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes the cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotuctants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3 ##STR1##

Other References

  • Srebnik, J. Chem. Soc., Perkin Trans, I, pp. 1423--1427 (1987).
  • Vree, J. Chromatogr., vol. 74, pp. 209-224 (1972).
  • Adams, Experienta, vol. 33, pp. 1205-1204 (1997).
  • Usami, Chem. Pharm. Bull., vol. 47, pp. 1641-1645 (Nov. 1999).
  • Baek, J. Korean Chem. Soc., vol. 35, pp. 59-63 (1991).
  • Baek, S. et al., "Boron Trifluoride Etherate on Alumina --A Modified Lewis Acid Reagent. An Improved Synthesis of Cannabidiol.", Tetraheron Letters, 1985, vol. 26, No. 8, pp. 1083-1086
  • Rhee, M. et al., "Cannabinol Derivatives: Binding to Cannabinoid Receptors and Inhibition of Adenylylcyclase", J. Med. Chem., 1997, vol. 40, pp. 3228-323
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