Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers

Patent 6562369 Issued on May 13, 2003. Estimated Expiration Date:

December 14, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

Transdermal therapeutic system having improved delivery characteristics
Patent #: 4704282
Issued on: 11/03/1987
Inventor: Campbell , et al.

Transdermal matrix system
Patent #: 4789547
Issued on: 12/06/1988
Inventor: Song , et al.

Transdermal drug delivery device
Patent #: 4837027
Issued on: 06/06/1989
Inventor: Lee , et al.

Device for transdermal administration of active medicinal agents
Patent #: 5071657
Issued on: 12/10/1991
Inventor: Oloff, et al.

Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels
Patent #: 5152997
Issued on: 10/06/1992
Inventor: Ebert, et al.

Transdermal therapeutic composition
Patent #: 5362497
Issued on: 11/08/1994
Inventor: Yamada, et al.

Tricyclic compounds and method for treating allergic diseases
Patent #: 5432192
Issued on: 07/11/1995
Inventor: Sawanishi, et al.

5446070

Methods for providing testosterone and optionally estrogen replacement therapy to women
Patent #: 5460820
Issued on: 10/24/1995
Inventor: Ebert, et al.

Transdermal system for the administration of pharmacological compounds under pH-controlled conditions
Patent #: 5462744
Issued on: 10/31/1995
Inventor: Gupte, et al.

More ...

Inventors

Application

No. 737829 filed on 12/14/2000

US Classes:

424/449, Transdermal or percutaneous424/443, Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments424/445, Dressings424/447, Bandages with incorporated medicaments424/448, Pressure sensitive adhesive means514/944, GEL514/946, PENETRANT OR ABSORBENT (ENHANCES PENETRATION INTO SUBJECT TREATED)514/947Topical application

Examiners

Primary: Page, Thurman K.
Assistant: Ghali, Isis

Attorney, Agent or Firm

Foreign Patent References

0709088 EP. 05/13/1996
2692145 FR. 12/13/1993
2180835 JP. 07/13/1990
WO 99/49844 WO. 10/13/1999

International Classes

A61F 013/00
A61L 015/00

Abstract

A method is provided for increasing the permeability of skin or mucosal tissue to transdermally administered androgenic drugs. The method involves use of a specified amount of a hydroxide-releasing agent, the amount optimized to increase the flux of the androgenic drug through a body surface while minimizing the likelihood of skin damage, irritation or sensitization. Formulations and drug delivery systems for co-administering a hydroxide-releasing agent with an androgenic drug are provided as well.

Other References

U.S. patent application Ser. No. 09/465,098, Luo et al
U.S. patent application Ser. No. 09/569,889, Luo et al
Aungst et al. (1990), "Contributions of Drug Solubilization, Partitioning, Barrier Disruption, and Sovent Permeation to the Enhancement of Skin Permeation of Various Compounds with Fatty Acids and Amines," Pharmaceutical Research 7(7):712-71