Method and an apparatus for stimulating/ modulating biochemical processes using pulsed electromagnetic fields
Patent 6561968 Issued on May 13, 2003. Estimated Expiration Date: August 29, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A method for stimulating growth in biological tissue or sprouts, an apparatus and a use thereof employs fluctuating magnetic fields. The apparatus includes a pulse generator and a plurality of coils in which pulsed currents will cause fluctuating magnetic fields in a predetermined region holding the material to be stimulated. The fluctuating magnetic fields will induce an electric field in the material. An enhanced effect has been detected in the regions where the electric fields are largest. The coils include a number of pairs of coils having, during a given pulse, magnetic fields in opposite directions in order to provide field gradients in the cells, micro organisms or tissue. Selecting a suitable number, size and positioning of coils will provide a homogeneous electric field in the predetermined region, which does not have any undesirable peaked maxima. When four or more coils are used, they can be combined in pairs arranged on opposite sides of the predetermined region, and with the adjacent coils conducting current in opposite directions and the opposing coils conducting currents in the same direction. Thereby, the induced electrical fields add constructively inside the regions between the pairs of coils. In an apparatus for stimulating cell proliferation and differentiation, it is a desired feature that the generated fluctuations in the magnetic fields do not elicit action potentials of living cells since this will cause great inconvenience for the patient.
Other References
Article: Trock, David H. et al., "The Effect of Pulsed Electromagnetic Fields in the Treatment of Osteoarthritis of the Knee and Cervical Spine. Report of Randomized, Double Blind, Placebo Controlled Trials", pp. 1903-1911, The Journal of Rheumatology, 1994; 21-10
Article: Patino, Osvaldo et al., "Pulsed Electromagnetic Fields in Experimental Cutaneous Wound Healing in Rats", pp. 528-531, Journal of Burn Care & Rehabiliation, vol. 17, No. 6, Part 1, Mar. 1996
Article: Portier, Christopher, and Wolfe, Mary S. (editors), Assessment of Health Effects from Exposure to Power-Line Frequency Electric and Magnectic Fields, pp. 256-257, NIH Publication No. 98-3981, Aug. 1998
Article: Bassett, C.A.L. et al., "A Non-Operative Salvage of Surgically-Resistant Pseudarthroses and Non-Unions by Pulsing Electromagnetic Fields", pp. 128-142, Clinical Orthopaedics and Related Research, No. 124, May 1977
Article: Sisken, B.F. et al., "Stimulation of rat sciatic nerve regeneration with pulsed electromagnectic fields", pp309-316, Brain Research, 485, (1989)
Article: Bassett, C.A.L. et al., "Treatment of Ununited Tibial Diaphyseal Fractures with Pulsing Electromagnetic Fields",pp. 511-523, The Journal of Bone and Joint Surgery, vol. 63-A, No. 4, Apr. 198