U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Permanent amniocytic cell line, its production and use for the production of gene transfer vectors

Patent 6558948 Issued on May 6, 2003. Estimated Expiration Date: Icon_subject November 16, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Application

No. 714550 filed on 11/16/2000

US Classes:

435/325, ANIMAL CELL, PER SE (E.G., CELL LINES, ETC.); COMPOSITION THEREOF; PROCESS OF PROPAGATING, MAINTAINING OR PRESERVING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF ISOLATING OR SEPARATING AN ANIMAL CELL OR COMPOSITION THEREOF; PROCESS OF PREPARING A COMPOSITION CONTAINING AN ANIMAL CELL; CULTURE MEDIA THEREFORE424/233.1, Adenoviridae, adeno-like virus, or Parvoviridae (e.g., adenovirus, canine parvovirus, mink enteritis virus, hemorrhagic enteritis virus, feline panleukopenia virus, egg drop syndrome virus, etc.)435/69.1, Recombinant DNA technique included in method of making a protein or polypeptide435/70.1, Using tissue cell culture to make a protein or polypeptide435/320.1, VECTOR, PER SE (E.G., PLASMID, HYBRID PLASMID, COSMID, VIRAL VECTOR, BACTERIOPHAGE VECTOR, ETC.) BACTERIOPHAGE VECTOR, ETC.)435/366, Human435/372Blood, lymphatic, or bone marrow origin or derivative

Examiners

Primary: Park, Hankyel T.
Assistant: Brown, Stacy S.

Attorney, Agent or Firm

Foreign Patent References

  • WO 94/28152 WO. 12/12/1994
  • WO 97/00326 WO. 01/12/1997
  • WO 00/70071 WO. 11/12/2012

International Classes

C12N 005/00
C12P 021/06
C12P 021/04

Abstract

The invention relates to a permanent amniocytic cell line comprising at least one nucleic acid which brings about expression of the gene products of the adenovirus E1A and E1B regions. The present invention further relates to the production of a permanent amniocytic cell line and to its use for producing gene transfer vectors and/or adenovirus mutants. Further aspects are the use of amniocytes and of the adenoviral gene products of the E1A and E1B regions for producing permanent amniocytic cell lines.

Other References

  • Leiden Muscular Dystrophy pages.COPYRGT., Leiden University Medical Center [online, retrieved Mar. 20, 2002], Retrieved from the Internet: .
  • Byrd et al., "Malignant Transformation of Human Embryo Retinoblasts by Cloned Adenovirus 12 DNA," Nature 298:69-71, (1982)
  • European Patent Application No. 99201545.3, "Adenovirus Derived Gene Delivery Vehicles Comprising at least One Element of Adenovirus Type 35," Filed May 17, 1999
  • Fallaux et al., "Characterization of 911: A New Helper Cell Line for the Titration and Propagation of Early Region 1-Deleted Adenoviral Vectors," Human Gene Therapy 7:215-222 (1996)
  • Fallaux et al., "New Helper Cells and Matched Early Region 1-Deleted Adenovirus Vectors Prevent Generation of Replication-Competent Adenoviruses," Human Gene Therapy 9:1909-1917 (1998)
  • Gaffney et al., "Two Distinct Types of SV40-Transformed Human Amnion Cells," Cancer Research 30:871-879 (1970)
  • Gallimore et al., "Studies on Adenovirus Type-12 E1 Region: Gene Expression, Transformation of Human and Rodent Cells, and Malignancy," Cancer Cells 4:339-348 (1986)
  • Gallimore et al., "Transformation of Human Embryo Retinoblasts with Simian Virus 40, Adenovirus and Oncogenes," Anticancer Research 6:499-508 (1986)
  • Graham et al., "Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5," J. Gen. Virol. 36:59-72 (1977)
  • Plouzek and Chou, "Isolation and Characterization of a Human Amnion Epithelial Cell Line that Expresses the Pregnancy-Specific 댡-Glycoprotein Gene," Endocrinology 129:950-958 (1991)
  • Sack, "Human Cell Transformation by Simian Virus 40--A Review," In Vitro 17:1-19 (1981)
  • Schiedner et al., "Efficient Transformation of Primary Human Amniocytes by E1 Functions of Ad5: Generation of New Cell Lines for Adenoviral Vector Production," Human Gene Therapy 11:2105-2116 (2000)
  • Walen and Arnstein, "Induction of Tumorigenesis and Chromosomal Abnormalities in Human Amniocytes Infected with Simian Virus 40 and Kirsten Sarcoma Virus," In Vitro Cell. Dev. Biol. 22:57-65 (1986)
  • Whittaker et al., "Isolation and Characterization of Four Adenovirus Type 12- Transformed Human Embryo Kidney Cell Lines," Molecular and Cellular Biology 4:110-116 (1984
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?