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US Patent 6551584 - Topical antibiotic composition for treatment of eye infection
US Patent Issued on April 22, 2003
Estimated Patent Expiration Date:
October 10, 2021Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Estimated Patent Expiration Date:
October 10, 2021Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.AbstractThere is provided a pharmaceutical composition suitable for topical administration to an eye, the composition comprising as active agent at least one oxazolidinone antibacterial drug, for example linezolid, in a concentration effective for treatment and/or prophylaxis of a gram-positive bacterial infection of an eye, and at least one ophthalmically acceptable excipient ingredient that reduces a rate of removal of the composition from the eye by lacrimation such that the composition has an effective residence time in the eye of about 2 to about 24 hours. The composition is, for example, an in situ gellable solution, suspension or solution/suspension.Other References
| Inventors
AssigneeApplicationNo. 974598 filed on 10/10/2001US Classes:424/78.04Ophthalmic preparationField of Search424/78.04, Ophthalmic preparation424/427OcularExaminersPrimary: Azpuru, CarlosAttorney, Agent or FirmUS Patent References3453259, 3863633, 3867519, 3868445, 3914402, 3960150, Bioerodible ocular deviceIssued on: 06/01/1976 Inventor: Hussain , et al.3963025, Ocular drug delivery device Issued on: 06/15/1976 Inventor: Whitaker , et al.3991759, Method and therapeutic system for treating aqueous deficient dry eye Issued on: 11/16/1976 Inventor: Urquhart4014335, Ocular drug delivery device Issued on: 03/29/1977 Inventor: Arnold4057619, Ocular therapeutic system with selected membranes for administering ophthalmic drug Issued on: 11/08/1977 Inventor: Higuchi , et al.4186184, Selective administration of drug with ocular therapeutic system Issued on: 01/29/1980 Inventor: Zaffaroni4281654, Drug delivery system for controlled ocular therapy Issued on: 08/04/1981 Inventor: Shell , et al.4303637, Medication indicated for ocular hypertension Issued on: 12/01/1981 Inventor: Shell , et al.4474751, Ophthalmic drug delivery system utilizing thermosetting gels Issued on: 10/02/1984 Inventor: Haslam , et al.4478818, Ocular preparation housing steroid in two different therapeutic forms Issued on: 10/23/1984 Inventor: Shell , et al.4559343, Nonirritating aqueous ophthalmic compositions comfort formulation for ocular therapeutic agents Issued on: 12/17/1985 Inventor: Han , et al.4861760, Ophthalmological composition of the type which undergoes liquid-gel phase transition Issued on: 08/29/1989 Inventor: Mazuel , et al.4911920, Sustained release, comfort formulation for glaucoma therapy Issued on: 03/27/1990 Inventor: Jani, et al.5134127, Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof Issued on: 07/28/1992 Inventor: Stella, et al.5164510, 5'Indolinyl-5ଲ-amidomethyloxazolidin-2-ones Issued on: 11/17/1992 Inventor: Brickner5190927, High-glyceryl, low-acetyl gellan gum for non-brittle gels Issued on: 03/02/1993 Inventor: Chang, et al.5192535, Ophthalmic suspensions Issued on: 03/09/1993 Inventor: Davis, et al.5212162, Use of combinations gelling polysaccharides and finely divided drug carrier substrates in topical ophthalmic compositions Issued on: 05/18/1993 Inventor: Missel, et al.5231188, Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents Issued on: 07/27/1993 Inventor: Brickner5275820, Stable suspension formulations of bioerodible polymer matrix microparticles incorporating drug loaded ion exchange resin particles Issued on: 01/04/1994 Inventor: Chang5376645, Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof Issued on: 12/27/1994 Inventor: Stella, et al.5403841, Use of carrageenans in topical ophthalmic compositions Issued on: 04/04/1995 Inventor: Lang, et al.5443505, Biocompatible ocular implants Issued on: 08/22/1995 Inventor: Wong, et al.5565571, Substituted aryl- and heteroaryl-phenyloxazolidinones Issued on: 10/15/1996 Inventor: Barbachyn, et al.5587175, Medical uses of in situ formed gels Issued on: 12/24/1996 Inventor: Viegas, et al.5627181, 6-membered nitrogen-containing heteroaryl-oxazolidinones Issued on: 05/06/1997 Inventor: Riedl, et al.5652238, Esters of substituted-hydroxyacetyl piperazine phenyl oxazolidinones Issued on: 07/29/1997 Inventor: Brickner, et al.5688791, Aryl group-or aromatic heterocyclic group-substituted aminoquinolone derivatives and anti-hiv agent Issued on: 11/18/1997 Inventor: Kimura, et al.5688792, Substituted oxazine and thiazine oxazolidinone antimicrobials Issued on: 11/18/1997 Inventor: Barbachyn, et al.5698574, 5-membered heteroaryl-oxazolidinones Issued on: 12/16/1997 Inventor: Riedl, et al.5837870, Process to prepare oxazolidinones Issued on: 11/17/1998 Inventor: Pearlman, et al.5869079, Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents Issued on: 02/09/1999 Inventor: Wong, et al.5874418, Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use Issued on: 02/23/1999 Inventor: Stella, et al.5876744, Highly bioadhesive and mucoadhesive compositions containing polyvinyl alcohol, polycarbophil and biopolymer for the treatment of skin conditions and as vehicles for active ingredients Issued on: 03/02/1999 Inventor: Della Valle, et al.6046177, Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations Issued on: 04/04/2000 Inventor: Stella, et al.6069145, Piperazinonephenyloxazolidinone derivatives and their use as antibacterial agents Issued on: 05/30/2000 Inventor: Betts6133248Polar drug of prodrug compositions with extended shelf-life storage and a method of making thereof Issued on: 10/17/2000 Inventor: Stella Foreign Patent References
International ClassA61K 031/74 |
