Devices and methods for cardiovascular reflex control

Patent 6522926 Issued on February 18, 2003. Estimated Expiration Date:

September 27, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3645267

3650277

Circulatory assist device and system
Patent #: 4014318
Issued on: 03/29/1977
Inventor: Dockum , et al.

RE30366

Arterial pressure control system
Patent #: 4256094
Issued on: 03/17/1981
Inventor: Kapp , et al.

Mutually noninterfering transcutaneous nerve stimulation and patient monitoring
Patent #: 4331157
Issued on: 05/25/1982
Inventor: Keller, Jr. , et al.

Endocardial lead having helically wound ribbon electrode
Patent #: 4481953
Issued on: 11/13/1984
Inventor: Gold , et al.

Apparatus for measuring the quantity of physical exercise
Patent #: 4525074
Issued on: 06/25/1985
Inventor: Murakami

Catheter with soft deformable tip
Patent #: 4531943
Issued on: 07/30/1985
Inventor: Van Tassel , et al.

Prosthetic sphincter
Patent #: 4551862
Issued on: 11/12/1985
Inventor: Haber

More ...

Inventors

Application

No. 671850 filed on 09/27/2000

US Classes:

607/44, Hypertension treating607/2Electrical therapeutic systems

Examiners

Primary: Jastrzab, Jeffrey R.
Assistant: Oropeza, Frances P.

Attorney, Agent or Firm

Townsend and Townsend and Crew LLP

Foreign Patent References

2001/0020177 Gruzdowich et al. 09/13/2012
WO 97/18856 WO. 05/13/1997
WO 99/26530 WO. 06/13/1999
WO 99/42039 WO. 08/13/1999
WO 99/42176 WO. 08/13/1999

International Class

A61N 001/18

Abstract

Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. By selectively and controllably activating baroreceptors, the present invention reduces excessive blood pressure, sympathetic nervous system activity and neurohormonal activity, thereby minimizing their deleterious effects on the heart, vasculature and other organs and tissues. A baroreceptor activation device is positioned near a baroreceptor, preferably in the carotid sinus and/or the aortic arch. The baroreceptor activation device may comprise a wide variety of devices which utilize mechanical, electrical, thermal, chemical or biological means to activate the baroreceptor. A control system may be used to generate a control signal to modulate the baroreceptor activation device. A sensor may be used to generate a signal indicative of cardiovascular function or other organ system function, and the control signal may be made a function of the sensor signal. The control system may include a processor and a memory, wherein the memory includes software containing an algorithm defining a relationship between the control signal and the sensor signal. The present invention also provides devices, systems and methods to selectively and controllably increase blood pressure, nervous system activity, and neurohormonal activity by inhibiting/dampening baroreceptor signals.

Other References

"Cardiovascular Reflexes From Ventricular & Coronary Receptors", Adv. Exp. Med. Biol., 1995, 381:157-74
"Non-Invasive Heat-Delivery To Arterial Stented Segments In Vivo: Effect of Heat on Intimal Hyperplasia", JACC, 1041-89, Feb. 2000
"The Haemodynamic Basis of Anginal Relief Produced By Stimulation of the Carotid Sinus Nerve", Acta Medica Academiae Scientiarum Hungaricae, 30 (1-2), pp. 61-65, 1973
Correspondence, The New England of Journal of Medicine, vol. 281, Jul. 3, 1969, No. 2
"Carotid Sinus Stimulation For the Treatment of Angina Pectoris", Official Journal of the Calif. Medical Assoc., vol. 112, No. 3, pp. 78-79, Mar. 1970
"Circulatory Effects of Carotid Sinus Stimulation & Changes in Blood Volume Distribution in Hypertensive Man", Acta. Physiol. Scand., 1981, 111:299-306, Mar. 1981
"Surgical Treatment of Hypertension with Reference to Baropacing", The Amer. Jour. Of Cardiology, vol. 17, May 1966, pp. 663-667
"Baropacing of the Carotid Sinus Nerve for Treatment of Intractable Hypertension", Zeitschrift Fur Kardiologie, band 64, Heft 4, pp. 368-374, 1975
"Laryngospasm Induced by a Carotid-Sinus-Nerve Stimulator", The New England Journ. Of Med., No. 13, pp. 709-710, undated
"Fine Structure of Baroreceptor Terminals in the Carotid Sinus of Guinea Pigs & Mice", Cell & Tissue Research, 170, pp. 95-112, 1976
"Structure of Rat Aortic Baroreceptors & Their Relationship to Connective Tissue", Journal of Neurocytology, pp. 401-414, 1979
"Baroreflex Anatomy", Human Baroreflexes in Health & Disease, pp. 19-30, 1992
"Implantation of a Carotid Sinus Nerve Stimulator", AORN Journal, pp. 53-56, Dec. 1969
"The Treatment of Heart Disease", Heart Disease, Earl N. Silber, 2^nd Edition, MacMillan Publishing Co., p. 1642, 1987
"Stimulation of the Carotid Baroreceptors Using a Radio-Frequency Method", Israel J. Med. Sci., vol. 1, No. 4, Jul. 1965, pp. 630-632
"Studies on the Carotid Body & the Carotid Sinus Effects on the Heart by Electrical Stimulation of the Carotid Sinus Wall", Jap. Heart J., vol. 13, No. 2, Mar. 1972, pp. 136-149
"Abstracts of the 40^th Scientific Sessions", Supplement II to Circulation, vols. XXXV & XXXVI, Oct. 1967, II-253, 1 sheet
"Clinical Experience with a Helical Bipolar Stimulating Lead", PACE, vol. 15, Part II, Oct. 1992, pp. 1545-1556
Schauerte et al., "Transvenous Parasympathetic Nerve Stimulation in the Inferior Vena Cava and Atrioventricular Conduction", J Cardiovasc Electrophysiol, Jan. 2000, 11(1):64-69, 1 page
Jeffrey J. Goldberger et al., "New Technique for Vagal Nerve Stimulation", Journal of Neuroscience Methods, 1999, pp. 109-114
Bilgutay,A.M. et al., "Baropacing, a New Concept in the Treatment of Hypertension", from Baroreceptors and Hypertension Proceedings of an International Symposium, Nov. 1965, p. 425-43