U.S. patents available from 1976 to present.
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Pulmonary delivery in treating disorders of the central nervous system

Patent 6514482 Issued on February 4, 2003. Estimated Expiration Date: Icon_subject September 19, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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Inventors

Assignee

Application

No. 665252 filed on 09/19/2000

US Classes:

424/45, Organic pressurized fluid128/203.15, Particulate treating agent carried by breathed gas424/43, EFFERVESCENT OR PRESSURIZED FLUID CONTAINING424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/220Tricyclo ring system having the seven-membered hetero ring as one of the cyclos

Examiners

Primary: Dees, Jose G.
Assistant: Haghighatian, M.

Attorney, Agent or Firm

Foreign Patent References

  • 2152684 CA. 06/13/1995
  • 0 496 307 EP. 07/13/1992
  • 61022019 JP. 01/13/1986
  • WO 91/16882 WO. 11/13/1991
  • WO 98/31346 WO. 07/13/1998
  • WO 98/46245 WO. 10/13/1998
  • WO 00/72827 WO. 12/13/2012
  • WO 01/95874 WO. 12/13/2012

International Classes

A61K 009/12
A61K 009/14
A61K 009/72

Abstract

A method of pulmonary delivery of a medicament, for example a dopamine precursor or a dopamine agonist, which includes administering to the respiratory tract of a patient in need of rescue therapy particles comprising an effective amount of a medicament. The particles are delivered to the pulmonary system and are released into the blood stream and delivered to the medicament's site of action in a time sufficiently short to provide the rescue therapy. In addition to the medicament, the particles can include other materials such as, for example, phospholipids, amino acids, combinations thereof and others. Preferred particles have a tap density of less than about 0.4 g/cm3.

Other References

  • Journal of the Neurological Sciences, vol. 150, Issue: 1001, supplement 1, p. S198, Sep. 199
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