U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Treatment of pain

Patent 6511982 Issued on January 28, 2003. Estimated Expiration Date: Icon_subject January 4, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Buspirone anti-anxiety method
Patent #: 4182763
Issued on: 01/08/1980
Inventor: Casten ,   et al.

Quinoline derivatives which are 5-hydroxytryptamine antagonists
Patent #: 4435405
Issued on: 03/06/1984
Inventor: Blackburn ,   et al.

Quinoline derivatives
Patent #: 4576953
Issued on: 03/18/1986
Inventor: Le Count

Quinoline derivatives which are 5-hydroxytryptamine antagonists
Patent #: 4607039
Issued on: 08/19/1986
Inventor: Le Count ,   et al.

Acetaminophen/hydroxyzine analgesic combinations
Patent #: 4794112
Issued on: 12/27/1988
Inventor: Cooper

Formulation of 5-HT agonist and NSAID for treatment of migraine Patent #: 5872145
Issued on: 02/16/1999
Inventor: Plachetka

Inventors

Assignee

Application

No. 754766 filed on 01/04/2001

US Classes:

514/252.15, Spiro ring system containing514/922SIDE EFFECT REDUCTION BY INCORPORATION OF A SECOND DESIGNATED INGREDIENT

Examiners

Primary: Krass, Frederick

Attorney, Agent or Firm

Foreign Patent References

  • 2222768 GB. 03/13/1990

International Class

A61K 031/497

Foreign Application Priority Data

1999-06-30 FR

Abstract

A method of treating pain with acetaminophen comprises the concurrent administration of buspirone. This combination of agents surprisingly results in a morphine-like analgesic response characterized by rapid onset, greater pain relief, and a longer duration of action.

Other References

  • Giordano, et al., "Antinociceptive effects of the novel anxiolytic buspirone in three pain tests in rats," Pain, 39, 1989, 109-113.
  • Giordano, et al., "Putative mechanisms of buspirone-induced antinociception in the rat," Pain,50, 1992, 365-372
  • Kishore-Kumar, et al., "Single doses of the serotonin agonists buspirone and m-chlorophenylpiperazine do not relieve neuropathic pain," Pain, 37, 1989, 223-227
  • Cao, et al., "Buspirone and 1 (2-pyrimidinyl)-piperazine attenuate xylazine-induced antinociception in the mouse," J. Pharm. Pharmacol., 1994, 46, 931-932
  • Pascual, et al., "Buspirone in primary headaches," Acta. Neurol. Scand., 1998, 97, 142
  • The Pharmacologic Basis of Therapeutics, 5th edition, Macmillan Publishing Co., 1975, 325-35
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