Benzofuran derivatives, process for the preparation of the same and uses thereof
Patent 6479536 Issued on November 12, 2002. Estimated Expiration Date: 
June 1, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
June 1, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesAmine derivatives of 2-nitro-3-phenylbenzofuran Heterocyclic 2,3-dihydrobenzofuran herbicides 3,5-dihydroxyheptanoic acid derivatives Patent #: 5266707 InventorsAssigneeApplicationNo. 857293 filed on 06/01/2001US Classes:514/416, The ring nitrogen is bonded directly to nonshared ring carbons of the five-membered hetero ring (e.g., isoindole, etc.)514/414, Additional hetero ring which is not part of the bicyclo ring system514/469, Bicyclo ring system having the hetero ring as one of the cyclos548/454, Additional polycyclo heterocyclic ring system attached directly or indirectly to the bicyclo ring system by nonionic bonding549/469, Benzene ring bonded directly to the hetero ring549/491Nitrogen attached indirectly to the hetero ring by nonionic bondingExaminersPrimary: Rao, DeepakAssistant: Patel, Nimeshkumar D. Attorney, Agent or FirmForeign Patent References
International ClassesA61K 031/40A61K 031/343 C07D 307/78 C07D 405/00 Foreign Application Priority Data1998-12-04 JPAbstractCompounds represented by the formula: ##STR1##wherein R1 and R2 are hydrogen atom, a hydrocarbon group or a heterocyclic group, or R1 and R2 may form, together with the adjacent carbon atom, a 3- to 8-membered homocyclic or heterocyclic ring,W indicates(i) a group represented by the formula: ##STR2## wherein ring B indicates a 5- to 7-membered ring, or(ii) a group represented by the formula: ##STR3## wherein R4 indicates (1) an aliphatic hydrocarbon group, which may be substituted with an aromatic group, or (2) an acyl group containing an aromatic group, R5 is hydrogen atom, a C1-6 alkyl, or an acyl group, provided that, when W is Wa, R3 is hydrogen atom, a hydrocarbon group or a heterocyclic group, when W is Wb, R3 indicates a C6-14 aryl group, or salts thereof or prodrugs thereof have an excellent action to inhibit neurodegeneration and the like as well as an excellent brain penetrability and are low in the toxicity, thereby being useful as prophylactic or therapeutic drugs for nerve degenerative diseases and the like.Other References
Field of SearchBenzene ring bonded directly to the hetero ringNitrogen attached indirectly to the hetero ring by nonionic bonding Bicyclo ring system having the five-membered hetero ring as one of the cyclos Additional hetero ring which is not part of the bicyclo ring system The ring nitrogen is bonded directly to nonshared ring carbons of the five-membered hetero ring (e.g., isoindole, etc.) Bicyclo ring system having the hetero ring as one of the cyclos Additional polycyclo heterocyclic ring system attached directly or indirectly to the bicyclo ring system by nonionic bonding |
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