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Synthesis of vicinal difluoro aromatics and intermediates thereof

Patent 6455744 Issued on September 24, 2002. Estimated Expiration Date: Icon_subject November 6, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Process for the preparation of aromatic fluoro compounds
Patent #: 5498807
Issued on: 03/12/1996
Inventor: Schach, et al.

Fluorination process
Patent #: 5900502
Issued on: 05/04/1999
Inventor: Skinner, et al.

Method of preparing fluoroaromatic compounds Patent #: 6008407
Issued on: 12/28/1999
Inventor: Nefedov, et al.

Inventors

Assignee

Application

No. 985786 filed on 11/06/2001

US Classes:

570/143Preparing benzene ring containing compound

Examiners

Primary: Higel, Floyd D.
Assistant: Shameem, Golam M. M.

Attorney, Agent or Firm

International Class

C07C 025/22

Abstract

A method of preparing vicinal difluoro aromatic compounds in high yield from hydroxy aromatic compounds and a method of preparing intermediates thereof. The hydroxy aromatic compound can be a mono-, bi- or tricyclic aromatic in which the rings are separate or fused. One or more of the rings can contain heteroatoms, such as oxygen, nitrogen, or sulfur, and can contain one or more substitutions, in addition to the hydroxy substitution.

Other References

  • N. Yoneda and T. Fukuhara, Tetrahedron, vol. 52, No. 1 (1996), pp. 23-36
  • C. Hu, et al., Journal of Fluorine Chemistry, vol. 48 (1990), pp. 29-35
  • J. Burdon and I. W. Parsons, Journal of Fluorine Chemistry, vol. 13 (1979), pp. 159-162
  • Sergey S. Laev and Vitalii D. Shteingarts, Journal of Flurine Chemistry, vol. 96 (1999), pp. 175-185
  • Mark W. Briscoe, et al., J. Chem. Soc., Chem. Commun., (1990), pp. 1127-1128
  • Antonella Profumo, et al., Heterocycles, vol. 51 (Nov. 7, 1999), pp. 1499-150
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