U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Ipratropium formulation for pulmonary inhalation

Patent 6455028 Issued on September 24, 2002. Estimated Expiration Date: Icon_subject April 23, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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More ...

Inventors

Assignee

Application

No. 841181 filed on 04/23/2001

US Classes:

424/45, Organic pressurized fluid424/46, Powder or dust containing424/434, Mucosal (e.g., nasal, etc.)424/435, Mouth424/489Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)

Examiners

Primary: Dees, Jose G.
Assistant: Haghighatian, Mina

Attorney, Agent or Firm

Foreign Patent References

  • WO 93/11743 WO. 06/13/1993
  • WO 93/11744 WO. 06/13/1993
  • WO 93/11745 WO. 06/13/1993
  • WO 93/15741 WO. 08/13/1993
  • WO 94/03153 WO. 02/13/1994
  • WO 96/18384 WO. 06/13/1996
  • WO 96/32099 WO. 10/13/1996
  • WO 96/32150 WO. 10/13/1996
  • WO 96/32151 WO. 10/13/1996

International Classes

A61K 009/12
A61K 009/14

Abstract

Pharmaceutical aerosol formulations are provided comprising substantially nonacicular particles of a bronchodilator selected from the group consisting of ipratropium and pharmacologically acceptable salts, solvates, hydrates, esters and isomers thereof. The described formulations include a propellant selected from the group consisting of a fluorocarbon propellant, a hydrogen-containing fluorocarbon propellant, and mixtures thereof. The formulations are substantially free of both surfactant and solvent. Methods of use and drug delivery devices are also provided.

Other References

  • Boehringer Ingelheim, Drug Information on Combivent.RTM., Feb. 1999 (obtained through on-line PDR).
  • Dellamary et al. (2000), "Hollow Porous Particles in Metered Dose Inhalers," Pharm. Res. 17(2):168-17
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