Matrices formed of polymer and hydrophobic compounds for use in drug delivery
Patent 6423345 Issued on July 23, 2002. Estimated Expiration Date: 
February 22, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
February 22, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3776001 Drug diffusion polymer system and method Particles incorporating surfactants for pulmonary drug delivery Prolonged release of GM-CSF Patent #: 5942253 InventorsAssigneeApplicationNo. 255179 filed on 02/22/1999US Classes:424/501, Contains solid synthetic resin424/484, Matrices424/486, Synthetic polymer424/487, Acrylic acid and derivatives424/488, Polysaccharides (e.g., cellulose, etc.)424/499Contains proteins or derivative or polysaccharides or derivativeExaminersPrimary: Webman, Edward J.Attorney, Agent or FirmForeign Patent References
International ClassesA61K 009/10A61K 009/16 A61K 047/30 AbstractA lipid or other hydrophobic or amphiphilic compound (collectively referred to herein as "hydrophobic compounds") is integrated into a polymeric matrix for drug delivery to alter drug release kinetics. In embodiments where the drug is water soluble, the drug is released over longer periods of time as compared to release from the polymeric matrix not incorporating the hydrophobic compound into the polymeric material. In contrast to methods in which a surfactant or lipid is added as an excipient, the hydrophobic compound is actually integrated into the polymeric matrix, thereby modifying the diffusion of water into the microparticle and diffusion of solubilized drug out of the matrix. The integrated hydrophobic compound also prolongs degradation of hydrolytically unstable polymers forming the matrix, further delaying release of encapsulated drug.Other References
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