U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings

Patent 6419952 Issued on July 16, 2002. Estimated Expiration Date: Icon_subject May 25, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient
Patent #: 3995631
Issued on: 12/07/1976
Inventor: Higuchi ,   et al.

Device having variable volume chamber for dispensing useful agent
Patent #: 4203440
Issued on: 05/20/1980
Inventor: Theeuwes

Osmotic device with hydrogel driving member
Patent #: 4327725
Issued on: 05/04/1982
Inventor: Cortese ,   et al.

Osmotic device with dual thermodynamic activity
Patent #: 4612008
Issued on: 09/16/1986
Inventor: Wong ,   et al.

Osmotic capsule
Patent #: 4627850
Issued on: 12/09/1986
Inventor: Deters ,   et al.

Osmotic device for administering certain drugs
Patent #: 4765989
Issued on: 08/23/1988
Inventor: Wong ,   et al.

Osmotic system comprising plurality of members for dispensing drug
Patent #: 4783337
Issued on: 11/08/1988
Inventor: Wong ,   et al.

Osmotic dosage system for delivering a formulation comprising liquid carrier and drug
Patent #: 5324280
Issued on: 06/28/1994
Inventor: Wong, et al.

Pharmaceutical tablet, completely coated, for controlled release of active principles that present problems of bio-availability linked to gastro-intestinal absorption Patent #: 6027748
Issued on: 02/22/2000
Inventor: Conte, et al.

Inventors

Application

No. 866036 filed on 05/25/2001

US Classes:

424/463, Coated capsules424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/452, With claimed designated perfecting feature in contents (e.g., excipient, lubricant, etc.)424/453, Telescoping two piece424/456, Gelatin424/457, Sustained or differential release424/468, Sustained or differential release type424/469, Discrete particles in supporting matrix424/473With porous, perforated, apertured, or sieved layer (e.g., dialyzing layer, microporous layer, etc.)

Examiners

Primary: Page, Thurman K.
Assistant: Di Nola-Baron, Liliana

Attorney, Agent or Firm

Foreign Patent References

  • 2148712 GB. 06/13/1985
  • 2182559 GB. 05/13/1987
  • WO9115196 WO. 10/13/1991

International Class

A61K 009/48

Abstract

A dosage form comprising a gelatin capsule formed with a composite wall and containing a liquid, active agent formulation where the wall comprises a barrier layer formed over the external surface of the gelatin capsule, an expandable layer formed over the barrier layer and a semipermeable layer formed over the expandable layer is described. The dosage forms and methods provide for the conversion of standard gelatin, liquid formulation capsules into controlled, release dosage forms that permit the controlled release of the active agent into the environment of use over time.

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