Signal generating oligonucleotide-based biosensor
April 19, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesUse of anti-idiotype antibodies in immunoassays Nucleic acid mediated electron transfer Systematic evolution of ligands by exponential enrichment: chimeric selex Detection of nucleic acids using G-quartets Nucleoside derivatives with photolabile protective groups Method for detecting a target molecule in a sample using a nucleic acid ligand Detectably labeled dual conformation oligonucleotide probes, assays and kits Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis Nucleic acid ligand diagnostic Biochip Patent #: 6242246 InventorsAssigneeApplicationNo. 529870 filed on 04/19/2000US Classes:435/6, Involving nucleic acid435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid435/288.3, Including a dish, plate, slide, or tray435/288.4, Including multiple compartments (e.g., wells, etc.)435/288.7, Including optical measuring or testing means536/24.3Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNAExaminersPrimary: Zitomer, Stephanie W.Attorney, Agent or FirmInternational ClassesC12Q 001/68C12M 001/34 C07H 021/04 C07H 021/02 AbstractThe present invention relates to oligonucleotide-based biosensors and a general method for their production and use. Specifically, the invention describes a novel signal-generating ligand complex comprising the combination of two or more aptamers linked together by a polymeric linker and further comprising a signaling system that provides a detectable signal upon binding of the signal-generating ligand complex to its target analyte.Other References
Field of SearchInvolving nucleic acidIncluding measuring or testing Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid Including a dish, plate, slide, or tray Including multiple compartments (e.g., wells, etc.) Including optical measuring or testing means DNA or RNA fragments or modified forms thereof (e.g., genes, etc.) Probes for detection of specific nucleotide sequences or primers for the synthesis of DNA or RNA |
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