Fermentative preparation process for and crystal forms of cytostatics
Patent 6380227 Issued on April 30, 2002. Estimated Expiration Date: 
September 7, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
September 7, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent References 3459731 Water-soluble steroid compounds Water soluble cyclodextrin polymers substituted by ionic groups and process for the preparation thereof Pharmaceutical composition and its nasal or vaginal use Method for treating taxol side-effects with G-CSF Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs Methods for administration of taxol Synthesis of epothilones, intermediates thereto, analogues and uses thereof Patent #: 6242469 InventorAssigneeApplicationNo. 656954 filed on 09/07/2000US Classes:514/365, 1,3-thiazoles (including hydrogenated)435/118, Containing two or more hetero rings514/367, Bicyclo ring system having the thiazole ring as one of the cyclos514/450, The hetero ring has at least seven members546/340, The chalcogen, X, is in a -C(=X)- group548/204, The chalcogen, X, is in a -C(=X)- group548/510, The chalcogen, X, is in a -C(=X)- group548/567The nitrogen is bonded directly to -C(=X)-, wherein X is chalcogen (e.g., 2 benzamidomethyl - pyrrolidines, etc.)ExaminersPrimary: Lilling, Herbert J.Attorney, Agent or FirmForeign Patent References
International ClassesC12P 017/16A61K 031/365 A61K 031/427 Foreign Application Priority Data1998-02-19 CHAbstractThe invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.Other References
Field of SearchThe chalcogen, X, is in a -C(=X)- groupContaining two or more hetero rings 1,3-thiazoles (including hydrogenated) Bicyclo ring system having the thiazole ring as one of the cyclos The hetero ring has at least seven members The nitrogen is bonded directly to -C(=X)-, wherein X is chalcogen (e.g., 2 benzamidomethyl - pyrrolidines, etc.) The chalcogen, X, is in a -C(=X)- group The chalcogen, X, is in a -C(=X)- group |
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