U.S. patents available from 1976 to present.
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Membrane enzyme reactor containing a plurality of biocatalyst-immobilized sheets

Patent 6379922 Issued on April 30, 2002. Estimated Expiration Date: Icon_subject September 20, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Immobilized glucoamylase reactor for preparing a low calorie beer
Patent #: 4430348
Issued on: 02/07/1984
Inventor: Duncombe ,   et al.

Continuous cheese-making process utilizing an immobilized rennet enzyme reactor Patent #: 4801463
Issued on: 01/31/1989
Inventor: Goldberg ,   et al.

Inventor

Assignee

Application

No. 665719 filed on 09/20/2000

US Classes:

435/41, MICRO-ORGANISM, TISSUE CELL CULTURE OR ENZYME USING PROCESS TO SYNTHESIZE A DESIRED CHEMICAL COMPOUND OR COMPOSITION426/7, FERMENTATION PROCESSES435/43, Preparing compound having a 1-thia-4-aza-bicyclo (3.2.0) heptane ring system (e.g., penicillin, etc.)435/44, By desacylation of the substituent in 6-position435/106, Preparing alpha or beta amino acid or substituted amino acid or salts thereof435/177, Enzyme or microbial cell is immobilized on or in an organic carrier435/289.1, Bioreactor435/294.1, Vessels or trays in series435/297.1Including semipermeable membrane or filter

Examiners

Primary: Naff, David M.

Attorney, Agent or Firm

International Classes

C12P 001/00
C12P 037/00
C12N 011/02
C12M 003/00
A23L 001/00

Abstract

An enzyme membrane reactor is designed to enhance the production efficiency of foods, pharmaceutical products, and other bioproducts. The reactor is formed of a cap and a container in which a plurality of the biocatalyst-immobilized sheets are located at an interval. The reactor works in such a way that a liquid reaction mixture is introduced into the container via an inlet of the container, thereby resulting in the synthesis of a bioproduct mixture which is collected via an outlet of the reactor. The immobilized biocatalyst is prepared by entrapping a biocatalyst with a gluten matrix. The immobilized biocatalyst is deposited on supporting meshes contained by a plurality of frames that are inserted in a plurality of pairs of grooves contained by two opposite side walls of the container. Deactivated biocatalyst-immobilized sheets are replaceable and recyclable. The biocatalyst-immobilized sheets of the reactor have a low trans-membrane pressure and a low intra-membrane diffusion resistance against the liquid reaction mixture, thereby resulting in an efficient production of bioproducts.

Other References

  • Prazeres et al., "Enzymatic Membrane Bioreactors and Their Application", Enzyme Microb. Technol., 16, pp. 738-750, 1994
  • Harrington et al., "Ceramic Membrane Microfilter as an Immobilized Enzyme Reactor", Enzyme Microb. Technol., 14, pp. 813-818, 199
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