U.S. patents available from 1976 to present.
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Biodegradable glass compositions and methods for radiation therapy

Patent 6379648 Issued on April 30, 2002. Estimated Expiration Date: Icon_subject February 1, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Thermally stable and crush resistant microporous glass catalyst supports and methods of making
Patent #: 3972721
Issued on: 08/03/1976
Inventor: Hammel ,   et al.

Composition and method for radiation synovectomy of arthritic joints
Patent #: 4889707
Issued on: 12/26/1989
Inventor: Day, et al.

Composition and method for radiation synovectomy of arthritic joints
Patent #: 5011797
Issued on: 04/30/1991
Inventor: Day, et al.

Composition and method for radiation synovectomy of arthritic joints Patent #: 5039326
Issued on: 08/13/1991
Inventor: Day, et al.

Inventors

Assignee

Application

No. 241892 filed on 02/01/1999

US Classes:

424/1.29, Coated, impregnated, or colloidal particulate (e.g., microcapsule, micro-sphere, micro-aggregate, macro-aggregate)252/644, As a source of radiation or heat424/1.37, Radionuclide or intended radionuclide in an organic compound424/451, Capsules (e.g., of gelatin, of chocolate, etc.)424/457, Sustained or differential release424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/490, Coated (e.g., microcapsules)501/33, Beads501/52, And aluminum or beryllium600/3Radioactive substance placed within body (e.g., inhaled, implanted, injected, etc.)

Examiners

Primary: Dudash, Diana
Assistant: Sharareh, Shahnam

Attorney, Agent or Firm

International Classes

A61K 051/00
A61M 036/14

Abstract

A nonradioactive glass in particulate form adapted for radiation therapy in a mammal comprise a biodegradable rare earth-lithium borate glass material of a specified composition which, upon being subjected to an effective amount of neutron irradiation, will produce a beta or gamma emitting radioisotope, the radioisotope being distributed throughout the glass material, the glass upon being introduced into a body fluid for radiation therapy being adapted to react therewith causing the radioisotope to form an insoluble compound on the surface of the glass material which is retained in the glass material and thereby prevented from escaping from the treatment site. Radioactive glasses and methods for carrying out radiation therapy with such radioactive glasses are also disclosed.

Other References

  • Devi et al. "Optical Properties of Pr3+ Ions in Lithium Borate Glasses" Physics and Chemistry of Glasses, vol. 37, No. 1 (1996) pp. 36-40
  • Nachimuthu et al. "Influence of Cations on the Optical Properties of Nd3+, Eu3+ and Er3+ Doped Borate Glasses" Physics and Chemistry of Glasses, vol. 38, No. 2 (1997) pp. 59-62
  • International Search Report for analogous PCT Application No. PCT/US00/02388 dated Jun. 14, 200
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