Composition for gene introduction into cell
Patent 6372714 Issued on April 16, 2002. Estimated Expiration Date: 
October 7, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
October 7, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesN[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor Liposomal-viral DNA complexes for treating disease Patent #: 6133243 InventorsAssigneeApplicationNo. 402452 filed on 10/07/1999US Classes:514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI264/4.1, Liquid encapsulation utilizing an emulsion or dispersion to form a solid-walled microcapsule (includes liposome)424/422, Implant or insert424/428, Bioerrodable, resorbable, or dissolving424/449, Transdermal or percutaneous424/450, Liposomes435/458The polynucleotide is coated with or encapsulated within a lipid containing material (e.g., liposome, etc.)ExaminersPrimary: Ketter, JamesAssistant: Schrizer, Richard Attorney, Agent or FirmForeign Patent References
International ClassA61K 007/46Foreign Application Priority Data1997-04-07 JPAbstractThe present invention is directed to a composition for gene transfer which composition contains a quaternary ammonium salt represented by formula (1): ##STR1##wherein A represents ##STR2##(wherein each of R1, R2, R3, R4 and R5, which are identical to or different from one another, represents a C9-C17 aliphatic group); X1 represents a halogen atom; and n is an integer from 1 to 10 inclusive; and a method for introducing a gene into a cell by use of the composition.The composition enables effective delivery and expression of a gene which previously could not be effectively expressed in cells due to the low ratio at which the gene is delivered into cells. Therefore, the composition is advantageously used as a gene transfer reagent or a pharmaceutical.Other References
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