Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions
Patent 6365178 Issued on April 2, 2002. Estimated Expiration Date: 
January 17, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
January 17, 2021. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesTransdermal release system for pharmaceutical preparation Cable connector with strain relief Preparation for transdermal drug administration Transdermal delivery of the active enantiomer of ketorolac Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents Patent #: 5985317 InventorsAssigneeApplicationNo. 764040 filed on 01/17/2001US Classes:424/449, Transdermal or percutaneous424/447, Bandages with incorporated medicaments424/448Pressure sensitive adhesive meansExaminersPrimary: Dodson, Shelley A.Attorney, Agent or FirmInternational ClassA61K 009/70AbstractA method of making a pressure sensitive matrix patch for transdermal delivery of a drug is disclosed. The method includes the steps of dissolving a hydrophilic salt form of the drug in the water phase of an aqueous dispersion of a hydrophobic pressure sensitive adhesive, casting the resulting mixture as a thin film, and evaporating the water. The physical stability of the drug in the film is excellent, and crystallization of the drug is inhibited. A method of increasing the transdermal flux of an acidic drug is also disclosed. | |
