U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

System and method for detection of a biological condition

Patent 6363772 Issued on April 2, 2002. Estimated Expiration Date: Icon_subject December 10, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3792272

3820901

3893771

Photoacoustic Raman spectroscopy
Patent #: 4197009
Issued on: 04/08/1980
Inventor: Berry ,   et al.

Photoacoustic Raman spectroscopy
Patent #: 4269509
Issued on: 05/26/1981
Inventor: Berry ,   et al.

Detection of lung cancer using breath luminescence
Patent #: 4534360
Issued on: 08/13/1985
Inventor: Williams

Apparatus for the photoacoustic detection of gases
Patent #: 4740086
Issued on: 04/26/1988
Inventor: Oehler ,   et al.

Method of detecting the presence of bronchogenic carcinoma by analysis of expired lung air
Patent #: 4772559
Issued on: 09/20/1988
Inventor: Preti ,   et al.

Method and apparatus for the transmision of an acoustic signal in a photoacoustic cell
Patent #: 5339674
Issued on: 08/23/1994
Inventor: Hammerich, et al.

Method and apparatus for material analysis
Patent #: 5348002
Issued on: 09/20/1994
Inventor: Caro

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Inventor

Application

No. 459251 filed on 12/10/1999

US Classes:

73/24.02, Produced by radiant energy73/24.01, By vibration73/24.06, Detector detail73/30.04, Detector detail73/31.05, Detector detail250/339.13, With gaseous sample356/437Gas

Examiners

Primary: Warden, Jill
Assistant: Sines, Brian

Attorney, Agent or Firm

Foreign Patent References

  • 19522774 DE. 01/13/1997

International Classes

G01N 023/00
G01N 021/00

Abstract

A system and method that allows for early detection of biological conditions, such as a disease, through analysis of appropriate gaseous samples. The system and method are particularly amenable to the early screening for diseases, such as lung cancer, through the detection of specific biomarkers when present in exhaled breath from an individual. A preferred system implements a CO overtone laser that generates radiation and directs it through a photoacoustic cell. The absorption of the radiation is detected acoustically, and the absorption characteristics are utilized in determining the presence of a specific biological condition.

Other References

  • B. Krotoszynski et al. , "Characterization of Human Expired Air: A Promising Investigative and Diagnostic Technique", pp. 239-244, Journal of Chromatographic Science, vol. 15, Jul. 1977
  • S.M. Gordon et al., "Volatile Compounds In Exhaled Air From Patients With Lung Cancer", pp. 1278-1282, Clinical Chemistry, vol. 31, No. 8, 1985
  • S. Bernegger et al., "Longitudinal Resonant Spectrophone for Co-Laser Photoacoustic Spectroscopy", pp. 125-132; Applied Physics, B44, 1987
  • H.J. O'Neill et al., "A Computerized Classification Technique For Screening For The Presence Of Breath Biomarkers In Lung Cancer", pp. 1613-1618, Clinical Chemistry, vol. 34, No. 8, 1988
  • Mitsui et al., "Clinical Chemistry", pp. 1993-1995, vol. 43, No. 10, 199
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