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Oral pulsed dose drug delivery system

Patent 6322819 Issued on November 27, 2001. Estimated Expiration Date: Icon_subject October 21, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

Pulsatile drug delivery system
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Patent #: 5002776
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Sustained pulsewise release pharmaceutical preparation
Patent #: 5011692
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Patent #: 5011694
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Processes for the preparation of delayed action and programmed release pharmaceutical forms and medicaments obtained thereby
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Inventors

Assignee

Application

No. 176542 filed on 10/21/1998

US Classes:

424/494, Cellulose derivatives424/472, Layered unitary dosage forms424/480Cellulose or derivative

Examiners

Primary: Dudash, Diana
Assistant: Berman, Alysia

Attorney, Agent or Firm

Foreign Patent References

  • 87/00044 WO. 01/13/1987
  • 90/09168 WO. 08/13/1990

International Class

A61K 009/16

Abstract

A multiple pulsed dose drug delivery system for pharmaceutically active amphetamine salts, comprising an immediate-release component and an enteric delayed-release component wherein (1) the enteric release coating has a defined minimum thickness and/or (2) there is a protective layer between the pharmaceutically active amphetamine salt and the enteric release coating and/or (3) there is a protective layer over the enteric release coating. The product can be composed of either one or a number of beads in a dosage form, including either capsule, tablet, or sachet method for administering the beads.

Other References

  • Conte, et al., "Press-coated tablets for time-programmed release of drugs," Biomaterials, 14(13):1017-1023 (1993)
  • Gazzaniga, et al., "Time-dependent oral delivery systems for colon targeting," S.T.P. Pharma Sciences, 5(1):83-88 (1995)
  • Gazzaniga, et al., "Oral Chronotopic Drug Delivery Systems: Achievement of Time and/or Site Specificity," Eur. J. Pharm. Biopharm, 40(4):246-250 (1994)
  • Pozzi, et al., "The Time Clock system: a new oral dosage form for fast and complete release of drug after a predetermined lag time," Journal of Controlled Release, 31:99-108 (1994)
  • Walia, et al., "Preliminary Evaluation of an Acqueous Wax Emulsion for Controlled-Release Coating," Pharmaceutical Development and Technology, 3(1):103-113 (1998)
  • Wilding, et al., "Gastrointestinal Transit and Systemic Absorption of Captopril from a Pulsed-Release Formulation," Pharmaceutical Research, 9(5):654-657 ((1992)
  • Xin Xu and Pink I. Lee, "Programmable Drug Delivery from an Erodible Association Polymer System," Pharmaceutical Research, 10(8):1144-1152 (1993
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