Asporogenic B anthracis expression system
Patent 6316006 Issued on November 13, 2001. Estimated Expiration Date: 
November 13, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
November 13, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.InventorsAssigneeApplicationNo. 346238 filed on 11/23/1994US Classes:424/246.1, Bacillus435/252.3, Transformants (e.g., recombinant DNA or vector or foreign or exogenous gene containing, fused bacteria, etc.)435/252.31, Bacillus (e.g., B. subtilis, B. thuringiensis, etc.)435/485Microorganism of the genus Bacillus is a host for the plasmid or episomeExaminersPrimary: Housel, James C.Assistant: Shaver, Jennifer Attorney, Agent or FirmInternational ClassC12N 015/00AbstractThis invention relates to a bacterial expression system for production of protective antigen (PA) against bacillus anthracis. Recombinant asporogenic B. anthracits that are derived from ƊSterne-1(pPA102) and show inability to bind the dye when grown on Congo Red Agar can be screened and asporogenic strains isolated using methods of the invention. organisms of the invention lacking spore-forming function may be killed by heat shock at temperatures as low as 60° C. for 60 minutes. Hence, contamination of the environment with viable spore-forming organisms is easily avoided and decontamination is easily accomplished.Other References
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