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US Patent 6306841 - Treatment of female sexual dysfunction

US Patent Issued on October 23, 2001
Estimated Patent Expiration Date: Icon_subject March 30, 2020Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

Methods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.

Other References

  • Frishman et al. (1992), "Evaluation of Astroglide, a New Vaginal Lubricant: Effect of Length of Exposure and Concentration on Sperm Motility," Fertility and Sterility 58(3):630
  • Levin (1991), "VIP, Vagina, Clitoral and Periurethral Glans--An Update on Human Female Genital Arousal," Exp. Clin. Endocrinol. 98(2):61-69
  • Semmens (1974), Medical Aspects of Human Sexuality 885-8

Inventors

Application

No. 539484 filed on 03/30/2000

US Classes:

514/149, Azoxy DOAI514/150, Acyclic nitrogen double bonded to acyclic nitrogen, acyclic nitrogen triple bonded to acyclic nitrogen or azide DOAI514/236.5, The ring nitrogens are bonded directly to each other (e.g., pyridazine, etc.)514/236.8, Ring chalcogen in the additional hetero ring (e.g., oxazole, etc.)514/530, Z contains a cyclopentyl or cyclopentene ring514/573Cyclopentyl or cyclopentene (e.g., prostaglandins, etc.)

Field of Search

514/149, Azoxy DOAI514/150, Acyclic nitrogen double bonded to acyclic nitrogen, acyclic nitrogen triple bonded to acyclic nitrogen or azide DOAI514/236.5, The ring nitrogens are bonded directly to each other (e.g., pyridazine, etc.)514/236.8, Ring chalcogen in the additional hetero ring (e.g., oxazole, etc.)514/573Cyclopentyl or cyclopentene (e.g., prostaglandins, etc.)

Examiners

Primary: Criares, Theodore J.

Attorney, Agent or Firm

US Patent References

3800038, 3948254, Novel drug delivery device
Issued on: 04/06/1976
Inventor: Zaffaroni
3967618, Drug delivery device
Issued on: 07/06/1976
Inventor: Zaffaroni
4014987, Device for delivery of useful agent
Issued on: 03/29/1977
Inventor: Heller ,   et al.
4112942, Method of preparing and administering a foam enema
Issued on: 09/12/1978
Inventor: Scaife
4128577, 15-Methyl- and 16-phenoxy-PGF2 ଱, amides
Issued on: 12/05/1978
Inventor: Nelson
4254145, Topical application of prostaglandin hypotensive agents
Issued on: 03/03/1981
Inventor: Birnbaum
4454339, 9-Fluoroprostaglandin derivatives, and use as medicinal agents
Issued on: 06/12/1984
Inventor: Skuballa ,   et al.
4507323, Treatment of psychosexual dysfunctions
Issued on: 03/26/1985
Inventor: Stern
4521421, Treatment of sexual dysfunction
Issued on: 06/04/1985
Inventor: Foreman
4564362, Vaginal device
Issued on: 01/14/1986
Inventor: Burnhill
4680312, Stable prostaglandin E gels utilizing colloidal silicon dioxide as a gel-forming agent
Issued on: 07/14/1987
Inventor: Johnson
4818517, Pharmaceutical preparation for obtaining a highly viscose hydrogel or suspension
Issued on: 04/04/1989
Inventor: Kwee ,   et al.
4961931, Method for the management of hyperplasia
Issued on: 10/09/1990
Inventor: Wong
4976692, Catheter particularly useful for inducing labor and/or for the application of a pharmaceutical substance to the cervix of the uterus
Issued on: 12/11/1990
Inventor: Atad
5190967, Medicaments for treating erectile disorders
Issued on: 03/02/1993
Inventor: Riley
5565466, Methods for modulating the human sexual response
Issued on: 10/15/1996
Inventor: Gioco, et al.
5698589, Water-based topical cream containing nitroglycerin and method of preparation and use thereof
Issued on: 12/16/1997
Inventor: Allen
5731339, Methods and formulations for modulating the human sexual response
Issued on: 03/24/1998
Inventor: Lowrey
5773020, Treatment of erectile dysfunction
Issued on: 06/30/1998
Inventor: Place, et al.
5773457, Compositions
Issued on: 06/30/1998
Inventor: Nahoum
6031002Method for enhancing female sexual response and a composition therefor
Issued on: 02/29/2000
Inventor: Wysor, et al.

Foreign Patent References

  • WO 99/20266 WO. 04/18/1999

International Classes

A61K 031/655
A61K 031/535
A61K 031/557
A61K 031/19

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