...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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AbstractMethods and formulations for treating female sexual dysfunction are provided. A pharmaceutical composition formulated so as to contain a selected vasoactive agent is administered to the vagina, vulvar area or urethra of the individual undergoing treatment. Suitable vasoactive agents are vasodilators, including naturally occurring prostaglandins, synthetic prostaglandin derivatives, endothelial-derived relaxation factors, vasoactive intestinal polypeptide agonists, smooth muscle relaxants, leukotriene inhibitors, and others. The formulations are also useful for preventing the occurrence of yeast infections, improving vaginal muscle tone and tissue health, enhancing vaginal lubrication, and minimizing excess collagen deposition. A clitoral drug delivery device is also provided.Other References
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ApplicationNo. 539484 filed on 03/30/2000US Classes:514/149, Azoxy DOAI514/150, Acyclic nitrogen double bonded to acyclic nitrogen, acyclic nitrogen triple bonded to acyclic nitrogen or azide DOAI514/236.5, The ring nitrogens are bonded directly to each other (e.g., pyridazine, etc.)514/236.8, Ring chalcogen in the additional hetero ring (e.g., oxazole, etc.)514/530, Z contains a cyclopentyl or cyclopentene ring514/573Cyclopentyl or cyclopentene (e.g., prostaglandins, etc.)Field of Search514/149, Azoxy DOAI514/150, Acyclic nitrogen double bonded to acyclic nitrogen, acyclic nitrogen triple bonded to acyclic nitrogen or azide DOAI514/236.5, The ring nitrogens are bonded directly to each other (e.g., pyridazine, etc.)514/236.8, Ring chalcogen in the additional hetero ring (e.g., oxazole, etc.)514/573Cyclopentyl or cyclopentene (e.g., prostaglandins, etc.)ExaminersPrimary: Criares, Theodore J.Attorney, Agent or FirmUS Patent References3800038, 3948254, Novel drug delivery deviceIssued on: 04/06/1976 Inventor: Zaffaroni3967618, Drug delivery device Issued on: 07/06/1976 Inventor: Zaffaroni4014987, Device for delivery of useful agent Issued on: 03/29/1977 Inventor: Heller , et al.4112942, Method of preparing and administering a foam enema Issued on: 09/12/1978 Inventor: Scaife4128577, 15-Methyl- and 16-phenoxy-PGF2 , amides Issued on: 12/05/1978 Inventor: Nelson4254145, Topical application of prostaglandin hypotensive agents Issued on: 03/03/1981 Inventor: Birnbaum4454339, 9-Fluoroprostaglandin derivatives, and use as medicinal agents Issued on: 06/12/1984 Inventor: Skuballa , et al.4507323, Treatment of psychosexual dysfunctions Issued on: 03/26/1985 Inventor: Stern4521421, Treatment of sexual dysfunction Issued on: 06/04/1985 Inventor: Foreman4564362, Vaginal device Issued on: 01/14/1986 Inventor: Burnhill4680312, Stable prostaglandin E gels utilizing colloidal silicon dioxide as a gel-forming agent Issued on: 07/14/1987 Inventor: Johnson4818517, Pharmaceutical preparation for obtaining a highly viscose hydrogel or suspension Issued on: 04/04/1989 Inventor: Kwee , et al.4961931, Method for the management of hyperplasia Issued on: 10/09/1990 Inventor: Wong4976692, Catheter particularly useful for inducing labor and/or for the application of a pharmaceutical substance to the cervix of the uterus Issued on: 12/11/1990 Inventor: Atad5190967, Medicaments for treating erectile disorders Issued on: 03/02/1993 Inventor: Riley5565466, Methods for modulating the human sexual response Issued on: 10/15/1996 Inventor: Gioco, et al.5698589, Water-based topical cream containing nitroglycerin and method of preparation and use thereof Issued on: 12/16/1997 Inventor: Allen5731339, Methods and formulations for modulating the human sexual response Issued on: 03/24/1998 Inventor: Lowrey5773020, Treatment of erectile dysfunction Issued on: 06/30/1998 Inventor: Place, et al.5773457, Compositions Issued on: 06/30/1998 Inventor: Nahoum6031002Method for enhancing female sexual response and a composition therefor Issued on: 02/29/2000 Inventor: Wysor, et al. Foreign Patent References
International ClassesA61K 031/655A61K 031/535 A61K 031/557 A61K 031/19 |