U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds

Patent 6306431 Issued on October 23, 2001. Estimated Expiration Date: Icon_subject April 7, 2020. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

D403778

D403779

D407822

D407824

D408923

D409757

D412751

D417283

D418606

3929131

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Inventors

Application

No. 545497 filed on 04/07/2000

US Classes:

424/449, Transdermal or percutaneous424/402, Wearing apparel, fabric, or cloth424/443, Web, sheet or filament bases; compositions of bandages; or dressings with incorporated medicaments424/447, Bandages with incorporated medicaments424/448, Pressure sensitive adhesive means514/817, ANESTHETIC, TOPICAL514/937, DISPERSION OR EMULSION514/944, GEL602/41, BANDAGE STRUCTURE602/46Polymeric foam

Examiners

Primary: Dees, Jose G.
Assistant: Williamson, Michael A.

Attorney, Agent or Firm

Foreign Patent References

  • 2 163 956 A GB. 12/11/1988
  • 88/09169 WO. 01/11/1988
  • WO 97/01310 WO. 01/11/1997
  • WO 97/01311 WO. 01/11/1997
  • WO 97/01312 WO. 01/11/1997
  • WO 97/01313 WO. 01/11/1997
  • WO 97/36968 WO. 10/11/1997
  • WO 97/49361 WO. 12/11/1997
  • WO 98/28021 WO. 07/11/1998
  • WO 98/28024 WO. 07/11/1998
  • WO 98/29063 WO. 07/11/1998
  • WO 98/29064 WO. 07/11/1998
  • WO 98/29065 WO. 07/11/1998
  • WO 98/29066 WO. 07/11/1998
  • WO 98/29067 WO. 07/11/1998
  • WO 99/09917 WO. 03/11/1999
  • WO 99/9918 WO. 03/11/1999

International Class

A61F 013/02

Abstract

Methods and apparatus for improving administration of drugs through the use of heat and other physical means. The present invention relates to the use of heat and other physical means in conjunction with specially designed dermal drug delivery systems, conventional commercial dermal drug delivery systems, or drugs delivered into a sub-skin depot site via injection and other methods to alter, mainly increase, the drug release rate from the dermal drug delivery systems or the depot sites to accommodate certain clinical needs.

Other References

  • Arky, et al., Physicians' Desk Reference, 1997, pp. 1336-1340
  • Mack Publishing Company, "Stability of Pharmaceutical Products," Pharmaceutical Sciences, pp. 1481-1482, 1985
  • McCafferty, et al., "Comparative In Vivo and In Vitro Assessment of the Percutaneous Absorption of Local Anaesthetics," British Journal of Anaesthesia, vol. 60, (1988), 64-69
  • Woolfson, et al., "Concentration Response Analysis of Percutaneous Local Anaesthetic Formulations," British Journal of Anaesthesia, vol. 61, (1988), pp. 589-592
  • McCafferty, et al., "In Vivo Assessment of Percutaneous Local Anaesthetic Preparations," British Journal of Anaesthesia, vol. 62, (1989), pp. 17-21
  • Knutson et al., "Solvent-Mediated Alterations of the Stratum Corneum," Journal of Controlled Release, vol. 11, (1990), pp. 93-103
  • Lycka, "EMLA, A New and Effective Topical Anesthetic," J. Dermotol, Surg. Oncol., vol. 18, (1992), pp. 859-862
  • McCafferty, et al., "New Patch Delivery System for Percutaneous Local Anaesthesia," British Journal of Anaesthesia, vol. 71, (1993) pp. 370-374
  • Woolfson, Percutaneous Local Anaesthesia, E. Horwood, N.Y. (1993), pp. 166-170
  • Astra USA, Inc., "EMLA Cream Product Information Form for American Hospital Formulary Service," (1993), pp. 1-28
  • "Room Temperature," Macmillan, U.S.A., Webster's New World College Dictionary, Third Edition, 1997, p. 1165
  • Florey, Klaus, Analytical Profiles of Drug Substances, vol. 15, 1986, pp. 150-231
  • Florey, Klaus, Analytical Profiles of Drug Substances, vol. 12, 1983, pp. 73-105
  • "Local Anesthetics, Parenteral, General Statement," AHFS Drug Information, 1992
  • Florey, Klaus, Analytical Profiles of Drug Substances, vol. 18, 1989, pp. 379-411
  • Sakamoto et al., "Dermal patch anesthesia: comparison of 10% lignocaine gel with absorption promoter and EMLA cream," Anesthesia, (1993), vol. 48, pp. 390-392
  • Dvoretzky, Israel, M.D., Hyperthermia Therapy for Warts Utilizing a Self-administered Exothermic Patch, Dermal Surgery, (1996), vol. 22, pp. 1035-1039
  • Stern Peter, M.D. and Levine, Norman, M.D., "Controlled Localized Heat Therapy in Cutaneous Warts," Arch. Dermatol, (Jul. 1992), vol. 128, pp. 945-94
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