U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Enamel matrix related polypeptide

Patent 6300062 Issued on October 9, 2001. Estimated Expiration Date: Icon_subject October 18, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Assignee

Application

No. 732749 filed on 10/18/1996

US Classes:

435/6, Involving nucleic acid424/9.322, Polymer containing (e.g., polypeptide, synthetic resin, etc.)424/189.1, Hepatitis virus424/192.1, Fusion protein or fusion polypeptide (i.e., expression product of gene fusion)530/300, PEPTIDES OF 3 TO 100 AMINO ACID RESIDUES530/350, PROTEINS, I.E., MORE THAN 100 AMINO ACID RESIDUES530/356, Collagen536/23.5Encodes an animal polypeptide

Examiners

Primary: Zitomer, Stephanie W.

Attorney, Agent or Firm

Foreign Patent References

  • WO 89/084441 WO. 09/12/1989

International Class

C12Q 001/68

Foreign Application Priority Data

1995-07-13 SE

Abstract

The invention relates to novel nucleic acid fragments encoding polypeptides which are capable of mediating contact between enamel and cell surface. The invention also relates to expression vectors containing the nucleic acid fragments according to the invention for production of the protein, organisms containing said expression vector, methods for producing the polypeptide, compositions comprising the polypeptides, antibodies or antibody fragments recognizing the polypeptides, and methods for treating various hard tissue diseases or disorders.

Other References

  • Tuszynski, et al., Biological Activities of Peptides and Peptide Analoques Derived from Common Sequences Present in Thrombospondin, Properdin, and Malarial Protein, Journal of Cell Biology, vol. 116, pp. 209-217, 1992
  • Nasman and Hammarstom, Indluence of the antineoplastic agent cyclophosphamide on dental development in rat molars, Acta Odontol Scand , vol.54, pp. 287-294, 1996
  • Brandsten, et al., Coronal Dentinal Nodules Induced by Single or Multiple Injections of HEBP in Young Rats, Connective Tissue Research, vol. 32, pp. 275-279, 1994
  • Yamada and Kleinman, Functional domains of cell adhesion molecules, Current Opinion in Cell Biology, vol. 4, pp. 813-823, 1992
  • Staatz, et al., Identification of a Tetrapeptide Recognition Sequence for the ଱2ଲ.sub.1 Integrin in Collagen, Journal of Biological Chemistry, vol. 266, No. 12, pp. 7363-7367, 1991
  • Hu. et al., Sheathlin: Clonin, cDNA/Polypeptide Sequences, and Immunolocalization of Porcine Enamel Shealth Proteins, vol. 76., pp. 648-657, 1997
  • MacDougall, et al., Ameloblastin gene (AMBU) maps withing the critical region for autosomal document amelogenesis imperfecta at chromosome 4 or 21, Genomics, vol.41, pp. 115-118 (1997) (abtract only)
  • Matsuki, et al., A Compilation of Partial Sequences of Randomly Selected cDNA Clones from Rat Incisor, EMBL Database RN973. Accession No.: R46973, 1995
  • Matsuki, et al., A Compilation of Partial Sequences of Randomly Selected cDNA Clones from Rat Incisor, EMBL Database Entry RN992, Accession No.: R46992, 1995
  • Cerny, et al., A Novel Gene Expressed in Rat Ameloblasts Codes for Proteins with Cell binding Domains, Journal of Bone and Mineral Research, vol. 11, No. 7, pp. 883-891, 1996
  • Krebsbach, et al., Full-Length Sequence, Localization, and Chromosomal Mapping of Ameloblastin, The Journal of Biological Chemistry, vo. 271, No. 8, pp. 4431-4435, 1996
  • Krebabach et al. 271: 4431-4435, 1996.
  • Santoro, SA GenBank Accession # R28043, 1992.
  • Gibson et al. Genbank Acession No. A37998, 1991.
  • GenBank Sequence Listing Summaries of tetrapeptide matche
PatentsPlus Images
Enhanced PDF formats
loading...
PatentsPlus: add to cart
PatentsPlus: add to cartSearch-enhanced full patent PDF image
$9.95more info
 
Sign InRegister
Username  
Password   
forgot password?