U.S. patents available from 1976 to present.
U.S. patent applications available from 2005 to present.

Fat-binding polymers

Patent 6299868 Issued on October 9, 2001. Estimated Expiration Date: Icon_subject July 14, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

3780171

3923972

Inhibitor preparation for the absorption of lipids, based on diethylaminoethyldextran
Patent #: 4160826
Issued on: 07/10/1979
Inventor: Fischetti

Method for controlling obesity
Patent #: 4211765
Issued on: 07/08/1980
Inventor: Johnson ,   et al.

Polyether ionophores as antiobesity and hypotriglyceridemic agents
Patent #: 4218443
Issued on: 08/19/1980
Inventor: Comai ,   et al.

Method for controlling blood triglycerides
Patent #: 4265879
Issued on: 05/05/1981
Inventor: Fields ,   et al.

Polyether ionophores as antiobesity and hypotriglyceridemic agents
Patent #: 4302450
Issued on: 11/24/1981
Inventor: Comai ,   et al.

Weight control with fat imbibing polymers
Patent #: 4432968
Issued on: 02/21/1984
Inventor: Page ,   et al.

Leucine derivatives
Patent #: 4598089
Issued on: 07/01/1986
Inventor: Hadvary ,   et al.

Stabilized enzymes liquid detergent composition containing lipase and protease
Patent #: 4959179
Issued on: 09/25/1990
Inventor: Aronson, et al.

More ...

Inventors

Application

No. 353329 filed on 07/14/1999

US Classes:

424/78.35, Nitrogen or sulfur containing monomer424/78.31, Polymer from ethylenic monomers only424/78.38Oxygen heterocycle

Examiners

Primary: Travers, Russell
Assistant: Wang, S.

Attorney, Agent or Firm

Foreign Patent References

  • 0 050 347 EP. 04/13/1982
  • 0 129 748A EP. 01/13/1985
  • 0 381 262 EP. 08/13/1990
  • 2 081 400 FR. 12/13/1971
  • 06 321787 JP. 11/13/1994
  • WO 89/07455 WO. 08/13/1989

International Classes

A61K 031/795
A61K 031/74
A61K 031/77

Abstract

The present invention relates to a method for treating obesity, a method for reducing the absorption of dietary fat, and a method for treating hypertriglyceridemia in a patient and to particular polymers for use in the methods or in a manufacture of a medicament. The methods comprise the step of orally administering to a mammal, such as a human, a therapeutically effective amount of one or more fat-binding polymers. The administration of the fat-binding polymer of the invention facilitates the removal of fat from the body prior to digestion, with minimal side effects and low toxicity. In a preferred embodiment, the one or more fat-binding polymers are administered in combination with one or more lipase inhibitors, for example, lipstatin and tetrahydrolipstatin.

Other References

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  • Gargouri, Y., et al., "Covalent inhibition of digestive lipases: an in vitro study," Biochimica et Biophysica Acta. 1344:6-37 (1997)
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  • Vainio, P., et al., "Inhibition of Lippoprotein Lipase by Benzene Boronic Acid Effect of Apolipoprotein C-II," Biochimica et Biophysica Acta. 711:386-390 (1982)
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  • Kawaguchi, K., et al. "Hesperidin as an Inhibitor of Lipases from Procine Pancreas and Pseudomonas," Biosci. Biotech. Biochem. 61(1):102-104 (1997)
  • Bochenek, W.J. and Rodgers, J.B., "Effect of Polyol Detergents on Cholesterol and Triglyceride Absorption," Biochimica et Biophysica Acta 489:503-506 (1977)
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  • Mannesse, M.L.M., et al., "Phosphonate analogues of triacylglycerols are potent inhibitor of lipase," Biochimica et Biophysica Acta. 1259:56-64 (1995)
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  • Han, L-K, et al., "Reduction in fat storage during chitin-chitosan treatment in mice fed a high-fat diet," International Journal of Obesity 23:174-179 (1999)
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