U.S. patents available from 1976 to present.
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Solid oral dosage forms of valsartan

Patent 6294197 Issued on September 25, 2001. Estimated Expiration Date: Icon_subject May 7, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventors

Assignee

Application

No. 202805 filed on 05/07/1999

US Classes:

424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/464, Tablets, lozenges, or pills424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)514/222.8, Polycyclo ring system having the six-membered hetero ring as one of the cyclos514/223.2, 1,2,4 - Benzothiadiazine - 1,1 - dioxides (including hydrogenated)514/223.5With additional active ingredient

Examiners

Primary: Page, Thurman K.
Assistant: Di Nola-Baron, Liliana

Attorney, Agent or Firm

Foreign Patent References

  • 2421 273 DE. 11/13/1974
  • 11 490 EP. 05/13/1980
  • 70 127 EP. 01/13/1983
  • 396 335A EP. 11/13/1990
  • WO93/15732 WO. 08/13/1993
  • 94 09778 WO. 05/13/1994
  • 95 24901 WO. 09/13/1995
  • 95 28927 WO. 11/13/1995
  • 95 29674 WO. 11/13/1995

International Class

A61K 009/20

Foreign Application Priority Data

1996-06-27 GB

Abstract

The present invention is concerned with solid dosage forms comprising a) valsartan and optionally HCTZ, and b) pharmaceutically acceptable additives suitable for the preparation of solid oral dosage forms by compression methods.

Other References

  • Lachman, L., Lieberman, HA and Kanig, JL. 1986. The Theory and Practice of Industrial Pharmacy. Lea & Febiger Eds. Philadelphia. pp. 318-320.
  • Muller, P., Cohen, T., de Gasparo, M., Sioufi, A., Racine-Poon, A., Howald, H. 1994. Angiotenwin II receptor blockade with single doses of valsartan in healthy, normotensive subjects. Eur. J. Clin. Pharmacol. 47: 231-245.
  • Fujimura, Y., Yamamoto, S., Ueda, H., Nakao, k. 1995. Antihypertensive effect of a combination of valsartan and hydrochlorothiazide, nifedipine or propranolol in spontaneously hypertensive rats. Yakuri to Chiryo 23: 3241-3247.
  • "Innovatives Antihypertensives," Therapiewoche 36, pp. 1882-1985 (1996)
  • Chemical Abstracts 124:220073 (1996)
  • Dialog: Derwent Drug File--Abstract AN:96-09445 (1996)
  • Dialog: Drug Data Report--Abstract AN 185987 (1992)
  • Dialog: JICST Eplus--Abstract AN:96A0157433 (1995)
  • Embase: Abstract 96015489 (1995)
  • Embase: Abstract AN-96-374183 (1996)
  • Embase: Abstract AN-97-027003 (1997)
  • Fujimura Y. et al., "Antihypertensive effect of a combination of Valsartan . . . ", Yakuri to Chiryo, vol. 23, No. 12, 1995, pp. 3241-3247
  • Grun, A. et al., "A comparison of the efficacy and tolerability . . . ", European Heart Journal, vol. 161, No. Sup. (1995), p. 61
  • Lachman, L. et al., "The Theory and Practice of Industrial Pharmacy," Lea & Febiger, 1986, pp. 318-320
  • Markham, A. et al., "Valsartan: a review of its pharmacology and therapeutic use . . . ", Drugs, vol. 54, No. 2, (1997) pp. 299-311
  • Toxlit: Abstract AN-96:69983 (1995
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