U.S. patents available from 1976 to present.
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Microemulsions as solid dosage forms for oral administration

Patent 6280770 Issued on August 28, 2001. Estimated Expiration Date: Icon_subject August 13, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Patent References

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Inventors

Application

No. 374393 filed on 08/13/1999

US Classes:

424/465, With claimed perfecting feature in contents (e.g., excipient, lubricant, etc.)424/464, Tablets, lozenges, or pills424/466, Effervescent424/474, Coated pills or tablets424/478, Gelatin containing424/489, Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)424/490, Coated (e.g., microcapsules)514/770, Siliceous or calcareous material (e.g., clay, earth, etc.)514/937, DISPERSION OR EMULSION514/938Oil-water type

Examiners

Primary: Spear, James M.

Attorney, Agent or Firm

International Classes

A61K 009/14
A61K 009/20
A61K 009/32
A61K 009/36
A61K 009/46

Abstract

Novel pharmaceutical compositions which improve the rate and/or extent of absorption of drugs are disclosed. The novel pharmaceutical compositions of the present invention comprise drug-containing microemulsions adsorbed onto solid particles which may be further formulated into solid dosage forms. The compositions and dosage forms of the present invention improve the bioavailability of a wide range of drugs including drugs that are known or suspected of having poor bioavailability by the utilization of several different mechanisms.

Other References

  • Microemulsion technology in the reformulation of cyclosporine: the reason behind the pharmacokinetic properties of Neoral, Ritschel, Clin. Transp. 1996: 10: 364-73
  • A comparison of two quality assessment methods for emulsions, Pather et al., J. Pharm. &Biomedical Analysis, 1995: 13: 1283-89
  • Spieras, et al., "Powdered Solution Technology: Principles and Mechanisms", J. Pharm. Res., 9(10):1351-58 (1992)
  • Sheth, A. and Jarowski, C.I., "Use of Powdered Solutions To Improve The Dissolution Rate of Polythiazide Tablets", Drug Dev. Ind. Pharm., 16(5):769-77 (1990)
  • Jonathan D. Eichman, "Mechanastic Studies On Effervescent-Induced Permeability Enhancement" Dissertation, University of Wisconsin-Madison (1997)
  • Guillemet, F. and Piculell, L., "Interactions in Aqueous Mixtures of Hydrophobically Modified Polyelectrolyte and Oppositely Charged Surfactant. Mixed Micelle Formation and Associative Phase Separation", J. Phys. Chem., 99:9201-09 (1995)
  • Nelson, Ph.D., E., "Part VXII. Physicochemical and Pharmaceutic Properties of Drugs that Influence the Results of Clinical Trials", Clin. Pharmacol. Ther., 3(5):673-81 (1962)
  • Ebert, W. R., "Soft Elastic Gelatin Capsules: A Unique Dosage Form", Pharm. Tech., 1(5):44-50 (1977
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