Patent 6276360 Issued on August 21, 2001. Estimated Expiration Date: September 2, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
Nasal dilators and methods for improving the breathing of individuals are provid. The dilator includes an elongated substrate having top and bottom surfaces and a pressure-sensitive adhesive disposed on the bottom surface. The elongated substrate can be made with resilient or spring material, or a resilient member can be bonded to the substrate to provide a gentle expanding force to the nasal wall tissue when the dilator is adhesively attached to the nose. This invention further includes an aromatic or transdermal substance, or both, disposed on the dilator to further improve breathing. Ideal aromatic substances include camphor and menthol. The aromatic substance can be disposed in a segregate form or in body activatable composition.
Other References
Letter from Daniel E. Cohen, President & CEO of CNS, Inc. dated Jun. 1, 1998
Letter from Daniel E. Cohen, M.D. (Chairman & CEO of CNS, Inc.) to Roland S. Spangler, Ph.d (Emerging Growth Equities, LLC) dated Sep. 9, 1996
3M-CNS, Inc., distributtion Agreement dated Aug. 2, 1995
Letter from Ronald Spangler, Ph.D (Managing Director of Emerging Growth Equities, LLC) to Richard E. Jahnke (CNS, Inc.) dated Aug. 27, 1996
Memo from John Neveaux (JLN Associates) to Andy Anderson dated Oct. 30, 1992
CNS, Inc. prospectus dated Mar. 29, 1996 (highlighted page 25)
Buchbauer G., Jirovetz L., Jaeger W., Plank C., Dietrich H., Title "Fragrance Compounds and Essential Oils with Sedative Effects Upon Inhalation", Source: Journal of Pharmaceutical Sciences 82 (6), 1993, pp. 660-664. (Abstract only)
Nagahara A., Benjamin H., Storkson, J., Krewson J., Sheng K., Liu W., Pariza M., Title "Inhibition of Benzo-A-Pyrene-Induced Mouse Forestomach Neoplasia by a Principal Flavor Component of Japanese-Style Fermented Soy Sauce", Source: Cancer Research 52 (7), 1992, pp. 1754-1756. (Abstract only)
Halim A.F ., Mashaly M.M., Sandra P., Title "Constituents of the Essential Oil of Mentha-Microphylla C. Koch.", Source: Egyptian Journal of Pharmaceutical Sciences 31 (1-4), 1990, pp. 437-442. (Abstract only)
Jungnickel P.W., Shaefer M.S., Maloney P.A., Campbell J.R., Shawaryn G.G., Goris G.B., Oliphant T.H., Title "Blind Comparison of Patient Preference for Flavored Colestid Granules and Questran Light", Source: Annals of Pharmacotherapy 27 (6), 1993, pp. 700-703. (Abstract only)
Schaller M., Korting H.C., Title "Allergic Airborne Contact Dermatitis from Essential Oils Used in Aromatherapy", Source: Clinical & Experimental Dermatology 20 (2), 1995, pp. 143-145. (Abstract only)
Mukhtar H., Katiyar S.K., Agarwal R., Title "Green Tea and Skin-Anticarcinogenic Effects", Source: Journal of Investigative Dermatology 102 (1), 1994, pp. 3-7. (Abstract only)
Everett T., Dennis M., Ricketts E., Title "Physiotherapy in Mental Health: A Practical Approach", Source: Everett T., M. Dennis and E. Ricketts (Ed.) Physiotherapy in Mental Health: A Practical Approach. xv+424p. Butterwoth-Heinemann Ltd., London, England, UK; Butterworth-Heinemann: Newton, Massachusetts, USA. XV+424P. ISBN 0-7506-1700-4. 1995. (Abstract only)
Komori T., Fujiwara R., Tanida M., Nomura J., Yokoyama M.M., Title "Effects of Citrus Fragrance on Immune Function and Depressive States", Source: Neuroimmunomodulation 2(3), 1995, pp. 174-180. (Abstract only)
Lis Balchin, Hart S., Title: A Preliminary Study of the Effect of Essential Oils on Skeletal and Smooth Muscle in Vitro, Source: Journal of Ethnopharmacology 58(3), 1997, pp. 183-187. (Abstract only)
Lindsay W.R., Pitcaithly D., N. Buntin., L. Broxholme, S. Ashby M., Title "A Comparison of the Effects of Four Therapy Procedures on Concentration and Responsiveness in People with Profound Learning Disabilities", Source: Journal of Intellectual Disability Research 41 (3), 1997, pp. 201-207. (Abstract only)
Morice A.H., Marshall A.E., Higgins K.S., Grattna T.J., Title "Effect of Inhaled Menthol on Citric Acid Induced Cough in Normal Subjects", Source: Thorax 49 (10), 1994, pp. 1024-1026. (Abstract only)
Eccles R., Griffiths D.H., Newton C.G., Tolley N.S., Title "The Effects of Menthol Isomers on Nasal Sensation of Airflow", Source: Clinical Otolaryngology & Allied Sciences (Oxford) 13 (1), 1988, pp. 25-30. (Abstract only)
Zaenker K.S., Toelle W., Bluemel G., Probst J., Title "Evaluation of Surfactant-Like Effects of Commonly Used Remedies for Colds", Source: Respiration 39 (3), 1980, pp. 150-157. (Abstract only)
Cohen B.M., Dressler W.E., Title: "Acute Aromatics Inhalation Modifies the Airways Effects of the Common Cold", Source: Respiration 43 (4), 1982, pp. 285-293. (Abstract only)
Eccles R., Jones A.S., Title "The Effect of Menthol on Nasal Resistance to Air Flow", Source: Journal of Laryngology & Otology 97 (8), 1983, pp. 705-709. (Abstract only)
Burrow A., Eccles R., Jones A.S., Title "The Effects of Camphor Eucalyptus and Menthol Vapor on Nasal Resistance to Air Flow and Nasal Sensation", Source: Acta Oto-Laryngologica 96 (1-2), 1983, pp. 157-162. (Abstract only)
Gal Fuzy M., Szente L., Szejtli J., Harangi J., Title "Cyclodextrin-Stabilized Volatile Substances for Inhalation Therapy", Source: Pharmazie 39 (8), 1984, pp. 558-559 (Abstract only)
Khadzhai Ya I., Bashura G.S., Sheherbakova N.R., Aslanyants A.A., Kuznetsova V.F., Title "The New Aerosol Preparation Camphomene", Source: Khimiko-Farmatsevticheskii Zhurnal 11 (1), 1977, pp. 147-149, (Abstract only)
Robinson M.K., Cruze C.A., Title "Preclinical Skin Sensitization Testing of Antihistamines: Guinea Pig and Local Lymph Node Assay Responses", Source: Food & Chemical Toxicology 34 (5), 1996, pp. 495-506. (Abstract only)
Radler S., Blaschek G., Title "Transdermal Absorption of Dimethindene in Man", Source: Achiv der Pharmazie (Weinheim) 328 (2), 1995, pp. 127-129. (Abstract only)
Binger Str., Title "Accumulation of Granulocytes in the Lung and Skin of Guinea Pigs: Inhibition by the Anti-H-1 Antiallergic Agent Epinastine", Source: Arzneimittel-Forschung 44 (12), 1994, pp. 1338-1342. (Abstract only)
Harada S., Takahashi Y., Nakagawa H., Title "Transdermal Administration of Emedastine", Source: Biological & Pharmaceutical Bulletin 16 (9), 1993, pp. 884-888. (Abstract only)
Robinson M.K., Parsell K.W., Breneman D.L., Cruze C.A., Title "Evaluation of the Primary Skin Irritation and Allergic Contact Sensitization Protential of Transdermal Triprolidine", Source: Fundamental & Applied Toxicology 17 (1), 1991, pp. 103-119. (Abstract only)
Miles M.V., Balasubramanian R., Pittman A.W., Grossman S.H., Pappa K.A., Smith M.F., Wargin W.A., Findlay J.W.A., Poust R.J., Frosolono M.F., Title "Pharmacokinetics of Oral and Transdermal Triprolidine", Source: Journal of Clinical Pharmacology 30 (6), 1990, pp. 572-575. (Abstract only)
B. Petruson, Title: "Two New Ways for Nasal Administration of Drugs with the Nasal Dilator Nozovent", Source: ENT-Department, University of Gotteborg, Sahlgren's Hospital, 413 45 Goteborg, Sweden
"Breathe Right" Nasal Strips, Manufactured by CNS, Inc., Chanhassen, MN
Article entitled "New Device Offers Relief for Snorers"
Letters from Ronald S. Spangler, Ph.D to Richard E. Jahnke (former president of CNS, Inc.) dated Aug. 27, 1996
Letter from Daniel E. Cohen, Chairman & CEO of CNS, Inc. to Ronald Spangler, Ph.D dated Sep. 9, 1996
CNS, Inc.-3M Distribution Agreement, SEC filing date Dec. 31, 1995 (highlighted pp. 49 and 50)
Ognyanov I., Fam Thi Bin Min, Todorova M., Kuleva L., Title "Chemotypes in Some Bulgarian Populations of Chrysanthemum-Vulgare L. Bernh.", Source: Comptes Rendus de L'Academie Bulgare des Sciences 45 (4), 1992, pp. 29-31
Zheng G.Q., Kenney P.M., Zhang J., Lam L.K.T., Title "Inhibition of Benzo-A-Pyrene-Induced Tumorigenesis by Myristicin A Volatile Aroma Constituent of Parsley Leaf Oil", Source: Carcinogenesis (Eynsham) 13 (10), 1992, pp. 1921-1923. (Abstract only)
Teopista N., Title "The Use of Aroma Therapy A.T. in the Management of People with Aids PWAS", Source: IXth International Conference on Aids and the IVth Std. World Congres. IXth International Conference on Aids in Affiliation with the IVth Std. World Congress Meeting, Berlin, Germany, Jun. 6-11, 1993. 649P. IXth International Conference on Aids: Berlin, Germany, 1993, 497. (Abstract only)
CNS Inc., Breathe Righ.RTM.Instructions, 1995
"Breathe Right", Nasal Strips, Manufactured by CNS, Inc., Chanhassen, MN
B4-U-BUY™ FYI,http://www.b4-u-buy.com/snorers.html, New Device Offers Relief For Snorers
Sigma Online Catalog, Nozovent
Hornung et al., "Effect of Nasal Dilators on Perceived Odor Intensity", Chem Senses 22:177-180, Apr. 1997
Hornung et al., "Effect of Nasal Dilators on Olfaction: I Nasal Structure and Sniffing Stragegies", pp 1-8, unpublished
Hornung et al., "Effect of Nasal Dilators on Olfaction: II Threshold, Intensity and Identification", pp 1-7, unpublishe