High throughput screening assay systems in microscale fluidic devices
Patent 6274337 Issued on August 14, 2001. Estimated Expiration Date: 
March 19, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
March 19, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethod and apparatus for dielectrophoretic manipulation of chemical species Laser-excitation fluorescence detection electrokinetic separation Solid-state optical assay imaging apparatus Silicon semiconductor wafer for analyzing micronic biological samples Capillary flow device Devices for use in chemical test procedures Imaging immunoassay detection system with background compensation and its use Method and device for moving molecules by the application of a plurality of electrical fields Capillary flow device Capillary flow device InventorsApplicationNo. 044557 filed on 03/19/1998US Classes:435/29, Involving viable micro-organism435/4, MEASURING OR TESTING PROCESS INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITION OR TEST STRIP THEREFORE; PROCESSES OF FORMING SUCH COMPOSITION OR TEST STRIP435/5, Involving virus or bacteriophage435/7.2, Involving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate435/7.21, Animal cell435/7.22, Parasite or protozoa435/7.23, Tumor cell or cancer cell435/7.24, Leukocyte (e.g., lymphocyte, granulocyte, monocyte, etc.)435/7.25, Erythrocyte435/7.3, Flagellar-antigen or pili-antigen435/7.31, Fungi (e.g., yeast, mold, etc.)435/7.32, Bacteria or actinomycetales435/287.1, Including measuring or testing435/287.2, Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid435/287.3, With sample or reagent mechanical transport means435/288.5, Including means for fluid passage between compartments (e.g., between wells, etc.)436/514, INVOLVING DIFFUSION OR MIGRATION OF ANTIGEN OR ANTIBODY436/536INVOLVING IMMUNE COMPLEX FORMED IN LIQUID PHASEExaminersPrimary: Le, Long V.Assistant: Pham, Minh-Chau T. Attorney, Agent or FirmForeign Patent References
International ClassC12Q 001/02AbstractThe present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.Other References
Field of SearchInvolving virus or bacteriophageInvolving a micro-organism or cell membrane bound antigen or cell membrane bound receptor or cell membrane bound antibody or microbial lysate Animal cell Parasite or protozoa Tumor cell or cancer cell Leukocyte (e.g., lymphocyte, granulocyte, monocyte, etc.) Erythrocyte Bacteria or actinomycetales Fungi (e.g., yeast, mold, etc.) Flagellar-antigen or pili-antigen Involving viable micro-organism Including measuring or testing Measuring or testing for antibody or nucleic acid, or measuring or testing using antibody or nucleic acid With sample or reagent mechanical transport means Including means for fluid passage between compartments (e.g., between wells, etc.) INVOLVING DIFFUSION OR MIGRATION OF ANTIGEN OR ANTIBODY INVOLVING IMMUNE COMPLEX FORMED IN LIQUID PHASE |
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