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US Patent 6271266 - Use of idebenone and analogues against ଲ amyloid induced cytotoxicity

US Patent Issued on August 7, 2001
Estimated Patent Expiration Date: Icon_subject November 9, 2018Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
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Abstract

A compound of the formula: ##STR1##wherein R1 represents a lower alkyl; R2 represents H, an optionally substituted alkyl or an optionally substituted alkenyl; R3 and R4 each represents an optionally substituted lower alkyl or a lower alkoxy, or R3 and R4 form, taken together, an optionally substituted butadienylene; and X1 and X2 each represents an optionally esterified or etherified hydroxy, or a salt thereof is useful for protecting cells from the cytotoxicity of ଲ-amyloid protein.

Other References

  • G. Weyer et al., "Efficacy and Safety of Idebenone in the Long-Term Treatment of Alzheimer's Disease: A Double-Blind, Placebo Controlled Multicentre Study", Human Psychopharmacology, vol. 11, pp. 53-65, (1996)
  • N. Ranen et al., "A Controlled Trial of Idebenone in Huntington's Disease", Movement Disorders, vol. 11, No. 5, pp. 549-554, (1996)
  • U. Senin et al., "Idebenone in Senile Dementia of Alzheimer Type: A Multicentre Study", Arch. Geront. Geriatr, vol. 15, pp. 249-260, (1992)
  • T. Nabeshima, "Nerve Growth Factor Strategy and Preparation of Animal Model for Alzheimer-Type Senil Dementia", Yakugaku Zasshi, vol. 115, No. 7, pp. 499-512, (1995)
  • Abstract to Canonico et al., "The role of free radicals and brain aging", G. Gerontol. 42(2), pp. 71-75, 1994.
  • Abstract to FR 2,703,591 A1, Oct. 14, 199

Inventors

Assignee

Application

No. 180463 filed on 11/09/1998

US Classes:

514/678Benzene ring containing

Examiners

Primary: Jones, Dwayne C.

Attorney, Agent or Firm

US Patent References

5059627Nerve growth factor secretion inducing composition
Issued on: 10/22/1991
Inventor: Goto, et al.

Foreign Patent References

  • 0 629 400 A1 EP. 12/09/1994
  • 629400 JP. 12/09/1994

International Class

A61K 031/185

Foreign Application Priority Data

1996-07-11 JP

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