Treatment of urinary incontinence by administration of 댑L-adrenoceptor agonists

Patent 6268389 Issued on July 31, 2001. Estimated Expiration Date:

January 11, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Abstract Claims Description Full Text

Patent References

3081222

3202660

3758476

Process for the manufacture of 2-arylamino-2-imidazoline derivatives and their salts
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Inventors

Assignee

Boehringer Ingelheim GmbH

Application

No. 227944 filed on 01/11/1999

US Classes:

514/398, Chalcogen or nitrogen bonded directly to the imidazole ring by nonionic bonding548/331.5, The nitrogen is bonded directly at the 2-position of the diazole ring548/333.1Benzene ring bonded directly to the nitrogen

Examiners

Primary: Higel, Floyd D.

Attorney, Agent or Firm

Raymond; R. P., Witkowski; T. X., Stempel; A. R.

Foreign Patent References

0071554 DE. 03/13/1970
1 929 950 DE. 03/13/1970
2 316 377 DE. 10/13/1974
28 06 811 A1 DE. 08/13/1979
28 54 659 A1 DE. 07/13/1980
0 030 616 B1 EP. 06/13/1981
0 070 084 A2 EP. 01/13/1983
0 081 924 A1 EP. 06/13/1983
0 081 923 A2 EP. 06/13/1983
0 073 394 A1 EP. 09/13/1983
0 117 102 A1 EP. 08/13/1984
0 149 140 A2 EP. 07/13/1985
0 236 636 A3 EP. 09/13/1987
0 416 841 A3 EP. 03/13/1991
0 599 697 A1 EP. 06/13/1994
0 682 028 A1 EP. 11/13/1995
WO 88/07995 A2 WO. 10/13/1988
94/08040 A1 WO. 04/13/1994

International Classes

A61N 013/00
A61N 013/10
A61K 031/416.8

Foreign Application Priority Data

1995-04-20 DE

Abstract

The present invention relates to the use of ଱lL -agonists for treating urinary incontinence.

Other References

Nordling, J. et al; "Sympathetic Influence on Striated Urethral Sphincter in Urinary Incontinence"; Prog. Clin. Biol. Res., vol. 78, pp. 101-103; 1981
Randall, W. C., et al; "Multiple Central Alpha2 Adrenoceptors Of Avian And Mammalian Species"; Biochem. Pharmacol., vol. 32, No. 12, pp. 1933-1940; 1983
Kontani, H. et al; "Effects of Adrenergic Agonists on an Experimental Urinary Incontinence Model in Anesthetized Rabbits"; Jpn. J. Pharmacol, vol. 58, No. 4, pp. 339-346; 1992
Van Savage, J. G., et al; "Effects of Alpha-Adrenergic Agonist on Neobladder Water and Electrolyte Transport"; Urology, vol. 43, No. 3, pp. 324-327, 1994
J. P. Hieble, et al; "Recent Progress in the Pharmacotherapy of Diseases of the Lower Urinary Tract"; Eur. J. Med. Chem.; pp. 269s-98s; 1995
Lehman, D., et al; "Verfahren zur Herstellung von Imidazolin-2-Derivaten"; Patentschrift 71 55