Method of treatment of glutathione deficient mammals
Patent 6262019 Issued on July 17, 2001. Estimated Expiration Date: 
April 29, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
April 29, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesMethods of treating mammals suffering from inflammation and pain Methods of treating mammals suffering from inflammation and pain Detection and/or determination of IgM, IgA, IgD and IgE immunoglobulins Biologically active whey protein concentrate Method of treatment of HIV-seropositive individuals with dietary whey proteins Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease Patent #: 5696109 InventorsAssigneeApplicationNo. 302217 filed on 04/29/1999US Classes:514/2, Peptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAI424/49, DENTIFRICES (INCLUDES MOUTH WASH)424/54, Ammonia, amine, or derivative thereof (e.g., urea, etc.)424/535, Milk or colostrum (e.g., butter, whey, etc.)424/655, Chromium514/7, Phosphorus containing514/12, 25 or more peptide repeating units in known peptide chain structure514/21, Produced by or extracted from animal tissue514/23, Carbohydrate (i.e., saccharide radical containing) DOAI514/251, Isoalloxazine (e.g., riboflavins, Vitamin B2, etc.)514/276, Thiamines (e.g., vitamin B1, etc.)530/365, Lactalbumin, e.g., milk source, etc.530/833Whey; cheeseExaminersPrimary: Carlson, Karen CochraneAssistant: Tu, Stephen Attorney, Agent or FirmInternational ClassesA01N 037/18A61K 038/02 AbstractGlutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intracellulary either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate), by way of inhibition of synthesis, or by subjecting cells to oxidant stress. Most cells, except for epithelia cells, do not have a direct transport capacity for intact GSH. Non-epithelial cells must either transport precursor substrates for GSH synthesis or salvage amino acids from circulating GSH for reuse in intracellular resynthesis. Dietary cysteine is a rate limiting substrate for the synthesis of glutathione and also inhibits GSH efflux. Although GSH is synthesized from precursors in virtually all cells, the liver is the main source of plasma GSH. Protection and support of liver function is paramount to elevating GSH levels. The disclosure is also of a unique combination of nutritional supplements including n-acetyl cysteine, vitamin C, l-glucosamine, n-acetyl d-glucosamine, quercitin, sylimarin, Alpha lipoic acid and high protein, low fat whey that are combined to support various bodily systems involved in glutathione synthesis, reutilization and storage; all intended to elevate glutathione concentration in the mammalian cell.Other References
Field of SearchPeptide containing (e.g., protein, peptones, fibrinogen, etc.) DOAIPhosphorus containing 25 or more peptide repeating units in known peptide chain structure Carbohydrate (i.e., saccharide radical containing) DOAI Produced by or extracted from animal tissue Isoalloxazine (e.g., riboflavins, Vitamin B2, etc.) Thiamines (e.g., vitamin B1, etc.) Ammonia, amine, or derivative thereof (e.g., urea, etc.) DENTIFRICES (INCLUDES MOUTH WASH) Milk or colostrum (e.g., butter, whey, etc.) Chromium Lactalbumin, e.g., milk source, etc. Whey; cheese |
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