Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
Patent 6258603 Issued on July 10, 2001. Estimated Expiration Date: 
May 20, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
May 20, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesInsecticidal N'-substituted-N,N'-diacylhydrazines Patent #: 5530028 InventorsAssigneeApplicationNo. 315451 filed on 05/20/1999US Classes:435/468, Introduction of a polynucleotide molecule into or rearrangement of a nucleic acid within a plant cell435/440, PROCESS OF MUTATION, CELL FUSION, OR GENETIC MODIFICATION549/366, Nitrogen attached indirectly to the hetero ring by acyclic nonionic bonding549/405, Having -C(=X)-, wherein X is chalcogen, bonded directly to the bicyclo ring system549/436, Having -C(=X)-, wherein X is chalcogen, bonded directly to the bicyclo ring system564/310HydrazinesExaminersPrimary: Schwartzman, Robert A.Attorney, Agent or FirmForeign Patent References
International ClassesC12N 015/82C07D 319/14 C07C 241/00 AbstractThis invention relates to an improved method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The improvement resides in a select group of non-steroid ligands which show improved activity over known ligands.Other References
Field of SearchAmino nitrogen attached to aryl ring or aryl ring system by an acyclic carbon or acyclic chainN-N containing (e.g., aminimine, hydrazine, etc.) Nitrogen attached indirectly to the hetero ring by acyclic nonionic bonding Having -C(=X)-, wherein X is chalcogen, bonded directly to the bicyclo ring system Having -C(=X)-, wherein X is chalcogen, bonded directly to the bicyclo ring system Hydrazines Symmetrical diaryl hydrazines METHOD OF INTRODUCING A POLYNUCLEOTIDE MOLECULE INTO OR REARRANGEMENT OF GENETIC MATERIAL WITHIN A PLANT OR PLANT PART PROCESS OF MUTATION, CELL FUSION, OR GENETIC MODIFICATION Introduction of a polynucleotide molecule into or rearrangement of a nucleic acid within a plant cell |
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