Stable glassy state powder formulations
October 17, 2016. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.Patent ReferencesPorous microspheres for drug delivery and methods for making same Protection of proteins and the like Low fusing temperature toner powder of cross-linked crystalline and amorphous polyester blends Storage of materials Powder coating composition low Tg and high Tg polymers with acid groups Method of protecting biological materials from destructive reactions in the dry state Method of protecting biological materials from destructive reactions in the dry state Patent #: 5290765 InventorsApplicationNo. 733225 filed on 10/17/1996US Classes:424/45, Organic pressurized fluid128/203.15, Particulate treating agent carried by breathed gas424/484, Matrices424/486, Synthetic polymer424/488, Polysaccharides (e.g., cellulose, etc.)424/489Particulate form (e.g., powders, granules, beads, microcapsules, and pellets)ExaminersPrimary: Page, Thurman K.Assistant: Fubara, B. Attorney, Agent or FirmForeign Patent References
International ClassA61K 009/12AbstractA powdered, dispersible composition having stable dispersibility over time is provided. The composition exhibits a characteristic glass transition temperature (Tg) and a recommended storage temperature (Ts), wherein the difference between Tg and Ts is at least about 10° C. (i.e. Tg -Ts is greater than 10° C.). The composition comprises a mixture of a pharmaceutically-acceptable glassy matrix and at least one pharmacologically active material within the glassy matrix. It may be further mixed with a powdered, pharmaceutically-acceptable carrier.It is particularly valuable in unit dosage from having a moisture barrier, in combination with appropriate labelling instructions.A process for producing a powdered dispersible composition is also provided, wherein the process comprises removing the solvent from a solution comprising a solvent, a glass former and a pharmacologically active material under conditions sufficient to form a glassy matrix having the pharmacologically active material within the matrix.Other References
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