Patent References
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Steroidal aerosol compositions and process for the preparation thereof Patent #: 4044126 Issued on: 08/23/1977 Inventor: Cook, et al.
Aerosol propellant compositions Patent #: 4174295 Issued on: 11/13/1979 Inventor: Bargigia , et al.
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Process for the preparation of a mixture of an anti-inflammatory steroid and a fluoro-chloro-hydrocarbon to be used as a propellant Patent #: 4347236 Issued on: 08/31/1982 Inventor: Tanskanen
Composition for treating asthma Patent #: 4405598 Issued on: 09/20/1983 Inventor: Brown
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Aerosol package having compressed gas propellant and vapor tap of minute size Patent #: 4940171 Issued on: 07/10/1990 Inventor: Gilroy
5118494
Aerosol drug formulations Patent #: 5126123 Issued on: 06/30/1992 Inventor: Johnson
Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content Patent #: 5182097 Issued on: 01/26/1993 Inventor: Byron, et al.
Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content Patent #: 5190029 Issued on: 03/02/1993 Inventor: Byron, et al.
Formulations for delivery of beclomethasone diproprionate by metered dose inhalers containing no chlorofluorocarbon propellants Patent #: 5202110 Issued on: 04/13/1993 Inventor: Dalby, et al.
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Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations Patent #: 5230884 Issued on: 07/27/1993 Inventor: Evans, et al.
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Medicinal aerosol formulations Patent #: 5605674 Issued on: 02/25/1997 Inventor: Purewal, et al.
Aerosol formulations containing P134a and particulate medicaments Patent #: 5653962 Issued on: 08/05/1997 Inventor: Akehurst, et al.
Aerosol formulations containing propellant 134a and fluticasone propionate Patent #: 5658549 Issued on: 08/19/1997 Inventor: Akehurst, et al.
Aerosol formulations containing P134a and salbutamol Patent #: 5674471 Issued on: 10/07/1997 Inventor: Akehurst, et al.
Canisters containing aerosol formulations containing P134a and fluticasone propionate Patent #: 5674472 Issued on: 10/07/1997 Inventor: Akehurst, et al.
Medicinal aerosol formulations Patent #: 5674473 Issued on: 10/07/1997 Inventor: Purewal, et al.
Canister containing aerosol formulations containing P134a and particulate medicaments Patent #: 5676929 Issued on: 10/14/1997 Inventor: Akehurst, et al.
Medicinal aerosol formulations Patent #: 5681545 Issued on: 10/28/1997 Inventor: Purewal, et al.
Canister containing aerosol formulations containing P134a and particulate medicaments Patent #: 5683676 Issued on: 11/04/1997 Inventor: Akehurst, et al.
Medicinal aerosol formulations Patent #: 5683677 Issued on: 11/04/1997 Inventor: Purewal, et al.
Cyclization process for making oxazolikinones Patent #: 5688962 Issued on: 11/18/1997 Inventor: Cox, et al.
Medicinal aerosol formulations Patent #: 5695743 Issued on: 12/09/1997 Inventor: Purewal, et al.
Aerosol formulations containing P134a and particulate medicaments Patent #: 5744123 Issued on: 04/28/1998 Inventor: Akehurst, et al.
Aerosol formulations containing beclomethasone dipropionate-1, 1, 1, 2-tetrafluoroethane solvate Patent #: 5833950 Issued on: 11/10/1998 Inventor: Taylor, et al.
Aerosol formulations containing P134A and/or P227 and particulate medicament Patent #: 5916540 Issued on: 06/29/1999 Inventor: Akehurst, et al.
Aerosol formulations containing P134a and particulate medicament Patent #: 5922306 Issued on: 07/13/1999 Inventor: Akehurst, et al.
Inventors
Assignee
Application No. 877198 filed on 06/17/1997
US Classes: 424/45 ,
Organic pressurized fluid 424/46 ,
Powder or dust containing 514/937 DISPERSION OR EMULSION
Examiners Primary:
Bawa, Raj
Attorney, Agent or Firm
Foreign Patent References 27 03 119 DE. 10/12/1990 134923 DK. 02/12/1997 0 372 777 EP. 06/12/1990 0 504 112 EP. 09/12/1992 437766 SE. 03/12/1985 86/04233 WO. 07/12/1986 90/07333 WO. 07/12/1990 91/04011 WO. 04/12/1991 91/11173 WO. 08/12/1991 91/11495 WO. 08/12/1991 91/11496 WO. 08/12/1991 91/14422 WO. 10/12/1991 92/00107 WO. 01/12/1992 92/06675 WO. 04/12/1992 92/08446 WO. 05/12/1992 92/08447 WO. 05/12/1992 92/11190 WO. 07/12/1992 92/22287 WO. 12/12/1992 92/22288 WO. 12/12/1992 93/11743 WO. 06/12/1993 93/11744 WO. 06/12/1993 93/11745 WO. 06/12/1993 93/11747 WO. 06/12/1993
International Class A61K 009/12
Foreign Application Priority Data 1991-12-12 GB
Abstract A pharmaceutical aerosol formulation which comprises particulate medicament selected from the group consisting of salmeterol, salbutamol, fluticasone propionate, beclomethasone dipropionate and physiologically acceptable salts and solvates thereof and a fluorocarbon or hydrogen-containing chlorofluorocarbon propellant, which formulation is substantially free of surfactant is disclosed. Also disclosed is a method of treating respiratory disorders which comprises administration by inhalation of an effective amount of the, pharmaceutical aerosol formulation which may be contained in a canister.
Other References Gennaro, A.R. (1985), Remington's Pharmaceutical Sciences (17th Ed.), Mack Publication Co., pp. 1670-1677 Oberholz, Frankfurter Allgemeine Zeitung, Oct. 1989, vol. 25, No. 207, pp. 7 Dalby et al., Pharmacetical Technology, Mar. 1990, vol. 14, No. 3, pp. 26-33 Amzacort™ carton, William H. Rorer, Inc., Fort Washington, Pennsylvania, USA 19034, 1986 Pharmaceutical Journal, Sep. 29, 1990, vol. 245, pp. 428-429 The Theory and Practice of Industrial Pharmacy, 2nd Ed., 1976, (Philadelphia, PA: Lea and Febiger), pp. 270 and 276-278 Handbook of Aerosol Technology, 2nd Ed., 1979 (New York, New York: Van Nostrand Reinhold Company), pp. 30, 32, 33, 166, 167, 232, 233) U.S. Senate Hearings, May 12-14 1987, 343-347, 437, (U.S. Government Printing Office, Washington, D.C., 1987), CIS: 1987-S321-26 Hagers Handbook of Pharmaceutical Practice, 1971, pp. 342-354 (Berlin: Springer-Verlag