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Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof

Patent 6245903 Issued on June 12, 2001. Estimated Expiration Date: Icon_subject August 13, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

Inventors

Assignee

Application

No. 09/373549 filed on 08/13/1999

US Classes:

536/7.4, Additional nitrogen containing536/18.5Processes

Examiners

Primary: Peselev, Elli

Attorney, Agent or Firm

International Classes

C07H 17/08 (20060101)
C07H 17/00 (20060101)

Foreign Application Priority Data

1998-08-21 CA

Abstract

A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate) has been obtained. Preparation of the novel form of azithromycin comprises the steps of dissolving azithromycin in isopropanol, followed by the slow addition of water to the organic solution.

Other References

  • Federal Register, vol. 62, No. 247, 67381, Dec. 25, 1997
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