Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
Patent 6245903 Issued on June 12, 2001. Estimated Expiration Date: August 13, 2019. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.
A novel form of azithromycin and processes for preparation of pure azithromycin monohydrate isopropanol clathrate (3 molecules of isopropanol for every 10 molecules of azithromycin monohydrate) has been obtained. Preparation of the novel form of azithromycin comprises the steps of dissolving azithromycin in isopropanol, followed by the slow addition of water to the organic solution.
Other References
Federal Register, vol. 62, No. 247, 67381, Dec. 25, 1997