U.S. patents available from 1976 to present.
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Method for fingerprinting utilizing an electronically addressable array

Patent 6245508 Issued on June 12, 2001. Estimated Expiration Date: Icon_subject August 27, 2018. Estimated Expiration Date is calculated based on simple USPTO term provisions. It does not account for terminal disclaimers, term adjustments, failure to pay maintenance fees, or other factors which might affect the term of a patent.

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Inventors

Application

No. 09/141286 filed on 08/27/1998

US Classes:

435/6, Involving nucleic acid257/E21.43, Recessing gate by adding semiconductor material at source (S) or drain (D) location, e.g., transist or with elevated single crystal S and D (EPO)257/E21.705, Assembly of devices consisting of solid-state components formed in or on a common substrate; assembly of integrated circuit devices (EPO)257/E29.267, With nonplanar structure (e.g., gate or source or drain being nonplanar) (EPO)422/68.1, Means for analyzing liquid or solid sample436/501BIOSPECIFIC LIGAND BINDING ASSAY

Examiners

Primary: Marschel, Ardin H.

Attorney, Agent or Firm

International Classes

B01J 19/00 (20060101)
C07B 61/00 (20060101)
C12Q 1/68 (20060101)
G11C 19/00 (20060101)
B01L 3/00 (20060101)
C07K 1/04 (20060101)
C07H 21/00 (20060101)
C07K 1/00 (20060101)
G11C 13/02 (20060101)
H01L 21/336 (20060101)
H01L 21/70 (20060101)
H01L 29/78 (20060101)
H01L 21/02 (20060101)
H01L 21/98 (20060101)
H01L 29/66 (20060101)

Abstract

A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out controlled reactions in microscopic formats. Preferably, a fluidic system flow a sample across an active area of the biochip, increasing diagnostic efficiency. Preferably, the fluidic system includes aflow cell having a window. Pulsed activation of the electrodes of the biochip are advantageously employed with the fluidic system, permitting more complete sampling of the materials within the biological sample. An improved detection system utilizes a preferably coaxially oriented excitation fiber, such as a fiber optic, disposed within a light guide, such as a liquid light guide. In this way, small geometry systems may be fluorescently imaged. A highly automated DNA diagnostic system results. Perturbation of the fluorescence signal during electronic denaturation is detailed and analyzed for analytical and diagnostic purposes. Such fluorescence perturbation information is combined with other information to provide improved analysis. DNA fingerprinting uses hybridizing DNA fragments of a given length and a capture sequence at a test site and then determining the level of reverse bias necessary to affect the hybridization, such as to de-hybridize, and determine the length of the DNA.

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